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    Category Health/Medical

    Nanoparticles Loaded with Component of Common Spice Kill Cancer cells

    July 25, 2017, Categories  Health/Medical, Biology/Biotechnology

    Nanoparticle delivery of curcumin induces cellular hypoxia and ROS-mediated apoptosis via modulation of Bcl-2/Bax in human neuroblastoma, Nanoscale (2017). DOI: 10.1039/C7NR02770B

    Attaching curcumin, a component of the common spice turmeric, to nanoparticles can be used to target and destroy treatment-resistant neuroblastoma tumor cells, according to a new study published in Nanoscale. The study, conducted in partnership by researchers at Nemours Children’s Hospital and the University of Central Florida, demonstrates a potentially novel treatment for neuroblastoma, the most common cancer in infants.

    “High-risk neuroblastoma can be resistant to traditional therapy, and survival can be poor...

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    High-Fat Diet in Pregnancy can cause Mental Health Problems in Offspring

    July 24, 2017, Categories  Health/Medical, Biology/Biotechnology

    Figure 8. (A) The location of area 10 of the prefrontal cortex (PFC) was determined using figures from Paxinos Stereotaxic Atlas (39). DAPI staining was used to differentiate the layers of the cortex, numbered 1–6. (B) Representative images of the differences seen in 5-HT fiber innervation of medial area 10 of the PFC between the four diet groups. (C) Exposure to a postweaning high-fat diet (HFD) decreased mean intensity of 5-HT immunoreactive signal in layer 1 of medial area 10 in the PFC (F1,16 = 7.662, p = 0.014). (D) 5-HT immunoreactivity in the same region was further affected by an interaction between gender and postweaning diet (F1,16 = 7.497, p = 0.015), with mean intensity decreased in postweaning HFD males compared to control males (F1,16 = 13.895, p = 0.002). Data shown as mean ± SEM. # denotes a postweaning diet effect, p < 0.05. Scale bars are 400 µm. Sample sizes for the 5-HT immunohistochemisty are as follows: CTR/CTR n = 6 (n = 2 males; n = 4 females), CTR/HFD n = 6 (n = 3 males; n = 3 females), HFD/CTR n = 6 (n = 3 males; n = 3 females), and HFD/HFD n = 6 (n = 3 males; n = 3 females).

    (A) The location of area 10 of the prefrontal cortex (PFC) was determined using figures from Paxinos Stereotaxic Atlas (39). DAPI staining was used to differentiate the layers of the cortex, numbered 1–6. (B) Representative images of the differences seen in 5-HT fiber innervation of medial area 10 of the PFC between the four diet groups. (C) Exposure to a postweaning high-fat diet (HFD) decreased mean intensity of 5-HT immunoreactive signal in layer 1 of medial area 10 in the PFC (F1,16 = 7.662, p = 0.014). (D) 5-HT immunoreactivity in the same region was further affected by an interaction between gender and postweaning diet (F1,16 = 7.497, p = 0.015), with mean intensity decreased in postweaning HFD males compared to control males (F1,16 = 13.895, p = 0.002). Data shown as mean ± SEM...

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    Laser Rx Reduces Eye Floaters

    July 22, 2017, Categories  Health/Medical, Biology/Biotechnology

    Subjective vs Objective Grading of Floater Resolution at 6 Months Using a 5-Level Qualitative Scale

    Subjective vs Objective Grading of Floater Resolution at 6 Months Using a 5-Level Qualitative Scale

    Patients reported improvement in symptoms of eye floaters after treatment with a laser, according to a study published by JAMA Ophthalmology. Floaters become more prevalent with age and although most patients grow accustomed to them, many find them bothersome, and they can worsen visual quality. Three management options exist for floaters: patient education and observation; surgery; and the laser procedure, YAG vitreolysis, of which there are limited published studies on its effectiveness for treating floaters.

    Chirag P. Shah, M.D., M.P.H., and Jeffrey S. Heier, M.D...

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    Why Sugary Drinks and Protein-Rich Meals don’t go well Together

    July 21, 2017, Categories  Health/Medical, Biology/Biotechnology

    Shanon L. Casperson, Clint Hall, James N. Roemmich. Postprandial energy metabolism and substrate oxidation in response to the inclusion of a sugar- or non-nutritive sweetened beverage with meals differing in protein content. BMC Nutrition, 2017; 3 (1) DOI: 10.1186/s40795-017-0170-2

    Shanon L. Casperson, Clint Hall, James N. Roemmich. Postprandial energy metabolism and substrate oxidation in response to the inclusion of a sugar- or non-nutritive sweetened beverage with meals differing in protein content. BMC Nutrition, 2017; 3 (1) DOI: 10.1186/s40795-017-0170-2

    Having a sugar-sweetened drink with a high-protein meal may negatively affect energy balance, alter food preferences and cause the body to store more fat, according to a study published in the open access journal BMC Nutrition...

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