Category Health/Medical

Highlights
•Diurnal changes in hypothalamic TCPTP coordinate feeding with energy expenditure
•Feeding represses hypothalamic TCPTP to increase energy expenditure
•TCPTP inhibits insulin signaling in AgRP neurons to repress energy expenditure
•Insulin signaling in AgRP neurons increases the browning of white fat

Scientists at Monash University’s Biomedicine Discovery Institute have found a mechanism by which the brain coordinates feeding with energy expenditure, solving a puzzle that has previously eluded researchers and offering a potential novel target for the treatment of obesity. Obesity – a major risk factor for many diseases including cardiovascular disease, Type 2 diabetes, liver disease and several cancers – is at epidemic levels in Australia.

Researchers from the Metabolic D...

With disease, when you decrease autophagy (a garbage disposal-like process where cells “eat” debris they produce) the disease process is exacerbated and when you increase it you get the opposite effect. Aggregation of polyglutamine expansion protein is a hallmark of Huntington’s disease and other neurodegenerative diseases. The picture shows that there are more aggregates of green fluorescence protein-labelled polyglutamine expansion protein in autophagy deficient worms (bottom) compared to normal worms (top).

Restricting how much you eat without starving has been shown to robustly extend lifespan in more than 20 species of animals including primates. How this works is still unclear...

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Multiple Sclerosis Journal, 2017; 135245851772264 DOI: 10.1177/1352458517722645

New research shows that resistance training protects the brain in persons with multiple sclerosis, which may delay the development of the disease. In the past, multiple sclerosis patients were advised not to exercise for fear of exacerbating the illness. However, it is now known that physical training can relieve many of the symptoms, including the excessive fatigue and mobility impairments that are often seen. New research now shows that resistance training may protect the nervous system and thus slow the progression of the disease.

This is the main finding of a study conducted by Aarhus University, Aarhus University Hospita...

Telomerase mRNA Reverses Senescence in Progeria Cells. Journal of the American College of Cardiology. DOI: 10.1016/j.jacc.2017.06.017

John P. Cooke, M.D., Ph.D studied cells from children with progeria, a rare condition marked by rapid aging that usually robs them of the chance to live beyond their early teens. They focused on progeria, because the condition tells them a lot about aging in general that’s ultimately relevant to all of us. “These kids are dying of heart attack and stroke at 13, 14, 15 years old,” Cooke said. Although current therapies are useful, they only add a year or two, on average, to the child’s life...