Category Health/Medical

This comparison shows images of breast tissue taken by the open-top light-sheet microscope (left), traditional pathology techniques (middle) and frozen sectioning during surgery (right). The first two images reveal crisp details of cellular and nuclear features, while the frozen-section image is distorted due to the challenges of freezing fatty breast tissues. While the formalin-fixed paraffin-embedded section requires hours of preparation, the open-top light-sheet microscope image is captured in minutes. Credit: Glaser et al., Nature Biomedical Engineering

Currently there’s no reliable way to determine during surgery whether the excised tissue is completely cancer-free at its margins – the proof that doctors need to be confident that they removed all of the tumor...

Microscope photo of adipose tissue. Credit: jxfzsy/iStock/Getty Images Plus

Discovered more than 2 decades ago, the hormone leptin has been widely hailed as the key regulator of leanness. Yet, the pivotal experiments that probe the function of this protein and unravel the precise mechanism of its action as a guardian against obesity are largely missing. Flier, the HMS George Higginson Professor of Physiology and Medicine, and Maratos-Flier, HMS professor of medicine at Beth Israel Deaconess Medical Center, have made significant contributions to the understanding of the metabolism of obesity and starvation in general, and of leptin in particular.

The commentary highlights what the authors say is a startling lack of experimental evidence detailing the biologic roles of leptin in metabolism, ...

Genes, Environment, and the Risk for Autism: Environment factors (ozone) can interact with genetic factors (copy number variation) to produce an even higher risk for autism than expected by adding the two risk factors, one that might not be found by studying the factors independently. Credit: Penn State University

Increased risk for autism when genetic variation and air pollution meet. A new analysis shows that individuals with high levels of genetic variation and elevated exposure to ozone in the environment are at an even higher risk for developing autism than would be expected by adding the 2 risk factors together...

Select Antieleptic drugs target mechanisms of epileptogenesis involving amyloid β and tau. Subclinical epileptiform activity in patients with Alzheimer’s disease can lead to accelerated cognitive decline and may be treated with AEDs like Levetiracetam.

Feasibility study suggests suppressing seizure-like activity may help patients. In the last decade, mounting evidence has linked seizure-like activity in the brain to some of the cognitive decline seen in patients with Alzheimer’s disease. Patients with Alzheimer’s disease have an increased risk of epilepsy and nearly half may experience subclinical epileptic activity – disrupted electrical activity in the brain that doesn’t result in a seizure but which can be measured by electroencephalogram (EEG) or other brain scan technology.

In a rece...