Category Health/Medical

A mediobasal hypothalamus (MBH) section shows microglia (green) in contact with AgRP neurons (red), which are critical hypothalamic neurons in the regulation of food intake and body weight. Credit: Image by the Suneil Koliwad Lab

Diet study finds link between brain inflammation and obesity in mice. Immune cells in the brain trigger overeating and weight gain in response to diets rich in fat, according to a new study in mice led by researchers from UC San Francisco and the University of Washington Medical Center. Brain-resident microglia could be targets for obesity treatments that might avoid many side effects of the obesity drugs currently in clinical use.

“Microglia are not neurons, but they account for 10 to 15% of the cells in the brain,” said Suneil Koliwad, MD, PhD, assistant profess...

A diagram of the VES-4, a scorpion-milking machine.

A new scorpion-milking robot designed could replace the traditional manual method. Scorpion venom is used in medical applications such as immunosuppressants, anti-malarial drugs and cancer research, but the extraction process can be potentially life-threatening. “This robot makes venom recovery fast and safe,” says Mr Mouad Mkamel who designed the robot with a team of researchers from Ben M’sik Hassan II University, Morocco.

“The extraction of scorpion venom is a very difficult task and usually takes at least two experimenters,” says Mr Mkamel. “There are numerous risks including potentially deadly scorpion stings and electric shocks from the stimulators used to extract the venom...

Highlights
•Plasma TMAO levels are elevated in type 2 diabetic patients
•Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
•Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
•Inhibition of Fmo3 promotes resistance to obesity

Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit: Marvin 101/Wikipedia

Over-the-Counter antioxidant lipoic acid holds promise in improving patients’ lives after an OHSU pilot study. Treatment options currently are limited for people suffering from secondary progressive MS. The randomized double-blind study involved 51 participants who completed the 2-year trial. 27 people were given a 1,200-milogram daily dose of lipoic acid, with the remaining 24 participants given a placebo. Researchers are using the findings from the pilot trial to design the expanded multi-site clinical trial to begin later this year in Portland and other sites that have yet to be finalized.

“These are high doses,” said Rebecca Spain, M.D...