
Mice lacking SCF in Krox20 lineage cells exhibit progressive hair graying. (A) A representative Scfflox/gfp; Krox20Cre mouse (top)
displaying hair graying along with aging as compared with a littermate Scfflox/gfp control (bottom). n = 20. (B) Pelage hairs plucked from P20
Scfflox/gfp; Krox20Cre mice showed distinct pigment levels in distal and proximal ends; newly developed hairs in the proximal side (arrowheads)
were absent of pigment. (C) Fontana-Masson staining confirmed the absence of melanin in the newly synthesized hairs (arrowheads)
in P32 Scfflox/gfp; Krox20Cre mice. (D) HF section revealing normal hair pigmentation in Scfflox/gfp; Krox20Cre mice at P9
followed by a rapid loss of pigmentation beginning from the hair matrix (arrowheads) at P11 and P13...






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