Category Health/Medical

Gut Microbes linked to Brain Structure in people with Irritable Bowel Syndrome

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome, 2017; 5 (1) DOI: 10.1186/s40168-017-0260-z

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome, 2017; 5 (1) DOI: 10.1186/s40168-017-0260-z

A new study at UCLA has revealed 2 key findings for people with irritable bowel syndrome about the relationship between the microorganisms that live in the gut and the brain. For people with IBS research shows for the first time that there is an association between the gut microbiota and the brain regions involved in the processing of sensory information from their bodies. The results suggest that signals generated by the brain can influence the composition of microbes residing in the intestine and that the chemicals in the gut can shape the human brain’s structure.

Additionally, they gained insight into the connections among chi...

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Skin Cells found at Root of Balding, Gray Hair

Mice lacking SCF in Krox20 lineage cells exhibit progressive hair graying. (A) A representative Scfflox/gfp; Krox20Cre mouse (top) displaying hair graying along with aging as compared with a littermate Scfflox/gfp control (bottom). n = 20. (B) Pelage hairs plucked from P20 Scfflox/gfp; Krox20Cre mice showed distinct pigment levels in distal and proximal ends; newly developed hairs in the proximal side (arrowheads) were absent of pigment. (C) Fontana-Masson staining confirmed the absence of melanin in the newly synthesized hairs (arrowheads) in P32 Scfflox/gfp; Krox20Cre mice. (D) HF section revealing normal hair pigmentation in Scfflox/gfp; Krox20Cre mice at P9 followed by a rapid loss of pigmentation beginning from the hair matrix (arrowheads) at P11 and P13. (E) Transverse HF section revealing hypopigmented hair shafts (arrowheads) in Scfflox/gfp; Krox20Cre mice at P11 and P13. (F) Quantification and statistical analysis of E showing a significant reduction of melanin density in Scfflox/gfp; Krox20Cre graying hair shafts. Melanin density was analyzed by ImageJ. Data are mean ± SEM from 100 randomly selected HFs in each group. (∗∗∗∗) P < 0.0001. (G) Gray Scfflox/gfp; Krox20Cre mice were depilated to stimulate hair regeneration; new hair shafts were completely absent of pigment. n = 3. Nuclei were stained with nuclear Fast Red in C–E. Bar, 100 µm.

Mice lacking SCF in Krox20 lineage cells exhibit progressive hair graying. (A) A representative Scfflox/gfp; Krox20Cre mouse (top)
displaying hair graying along with aging as compared with a littermate Scfflox/gfp control (bottom). n = 20. (B) Pelage hairs plucked from P20
Scfflox/gfp; Krox20Cre mice showed distinct pigment levels in distal and proximal ends; newly developed hairs in the proximal side (arrowheads)
were absent of pigment. (C) Fontana-Masson staining confirmed the absence of melanin in the newly synthesized hairs (arrowheads)
in P32 Scfflox/gfp; Krox20Cre mice. (D) HF section revealing normal hair pigmentation in Scfflox/gfp; Krox20Cre mice at P9
followed by a rapid loss of pigmentation beginning from the hair matrix (arrowheads) at P11 and P13...

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Cinnamon may Lessen Damage of High-Fat Diet in Rats

Cinnamon (1 tsp)

Cinnamon (1 tsp) copyright American Heart Association

Cinnamon may lessen the risk of cardiovascular damage of a high-fat diet by activating the body’s antioxidant and anti-inflammatory systems and slowing the fat-storing process, according to a preliminary animal study presented at the American Heart Association’s Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease 2017 Scientific Sessions.

In the study, researchers fed rats cinnamon supplements for 12 weeks along with a high-fat diet. They found: The rats weighed less and had less belly fat and healthier levels of sugar, insulin and fat in their blood, compared to rats that did not receive cinnamon with their high-fat foods...

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Student Creates 1st Synthetic Retina for the Visually Impaired

The retina replica consists of soft water droplets (hydrogels) and biological cell membrane proteins. Designed like a camera, the cells act as pixels, detecting and reacting to light to create a grey scale image. Credit: Oxford University

The retina replica consists of soft water droplets (hydrogels) and biological cell membrane proteins. Designed like a camera, the cells act as pixels, detecting and reacting to light to create a grey scale image. Credit: Oxford University

A synthetic, soft tissue retina developed by an Oxford University student could offer fresh hope to visually impaired people. Until now, all artificial retinal research has used only rigid, hard materials. The new research, by Vanessa Restrepo-Schild, a 24yo Dphil student and researcher at the Oxford University, Department of Chemistry, is the first to successfully use biological, synthetic tissues, developed in a laboratory environment...

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