Category Health/Medical

X-ray crystal structure of the human POT1-TPP1 telomere maintenance complex. POT1 is shown in salmon and TPP1 in lime color. Credit: The Wistar Institute

Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres – the ends of our chromosomes. The study explains how a group of genetic mutations associated with this protein complex contributes to various cancers. Telomeres are the protective structures at the end of chromosomes and are essential for the faithful replication and protection of our genome. Defects in telomere function can lead to genomic instability in cancer, while the gradual shortening of telomeres is associated with the aging of human cells...

A high-magnification micrograph of an ovarian clear cell carcinoma. The images show, focally, the characteristic clear cells with prominent nucleoli and the typical hyaline globules. A high-magnification micrograph of an ovarian clear cell carcinoma. The images show, focally, the characteristic clear cells with prominent nucleoli and the typical hyaline globules. Image: Nephron/CC BY-SA 3.0

‘Synthetic biomarkers’ could be used to diagnose ovarian cancer months earlier than now possible. Most ovarian cancer is diagnosed at such late stages that patients’ survival rates are poor. However, if the cancer is detected earlier, 5-year survival rates can be greater than 90%...

The degree of hair graying in male gender as an independent risk factor for coronary artery disease, a prospective study

Grey hair has been linked with an increased risk of heart disease in men, in research presented today at EuroPrevent 2017. “Ageing is an unavoidable coronary risk factor and is associated with dermatological signs that could signal increased risk,” said Dr Irini Samuel, a cardiologist at Cairo University, Egypt. Atherosclerosis and hair greying share similar mechanisms such as impaired DNA repair, oxidative stress, inflammation, hormonal changes and senescence of functional cells. This study assessed the prevalence of grey hair in patients with coronary artery disease and whether it was an independent risk marker of disease.

This was a prospective, observational study wh...

A bioactive foam could be used to replace skull bone lost to injury, surgery, or birth defect. Credit: Texas A&M University

A Rensselaer Polytechnic Institute team is developing a new material that can be used to replace skull bone lost to injury, surgery, or defect. The bioactive foam is malleable when exposed to warm saline (similar to a sponge), allowing surgeons to easily shape it to fit irregular defects in the skull, where it hardens in place. Once implanted in the skull, specially coated pores within the foam attract bone cells, naturally regenerating bone to replace the foam, which dissolves over time.

The foam – a shape memory polymer coated in a bioactive polydopamine – is intended as an alternative to materials currently used to treat cranio-maxillofacial gaps...