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    Category Health/Medical

    Unraveling the functional diversity of Longevity gene SIRT1

    March 28, 2017, Categories  Biology/Biotechnology, Health/Medical

    Highlights •SIRT1-ΔE2 is a tissue-restricted splice variant of SIRT1 •SIRT1-FL/SIRT1-ΔE2 are indistinguishable vis-à-vis intrinsic catalytic activities •The conserved exon 2 (E2) domain may act to tether substrates •E2 encodes molecular specificity of interactions and functions

    Highlights •SIRT1-ΔE2 is a tissue-restricted splice variant of SIRT1 •SIRT1-FL/SIRT1-ΔE2 are indistinguishable vis-à-vis intrinsic catalytic activities •The conserved exon 2 (E2) domain may act to tether substrates •E2 encodes molecular specificity of interactions and functions

    Two alternate forms of SIRT1 leads to the discovery of how molecular specificity is encoded. While the search for elixir of life has captivated human imagination for millennia, researchers around the world have put in efforts to extend healthy lifespan and reduce the burden of morbid diseases in an increasingly aging population...

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    Vitamin D decreases risk of Cancer, new study suggests

    March 28, 2017, Categories  Health/Medical, Biology/Biotechnology

    vit D pathway

    vit D pathway

    Increasing vitamin D levels may lower risk for developing cancer, according to a study conducted by Creighton University with cooperation from the University of California San Diego. The results of the study were released today in the Journal of the American Medical Association. The study, funded by the National Institutes of Health, is a randomized clinical trial of the effects of vitamin D supplementation on all types of cancer combined.

    en 55 years and older from 31 counties in Nebraska. Participants were randomly assigned to take either 2000 international units (IU) of vitamin D3 and 1500 mg. of calcium or identical placebos daily for 4 years...

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    Microrna treatment Restores Nerve Insulation, Limb Function in Mice with MS

    March 27, 2017, Categories  Health/Medical, Biology/Biotechnology

    This image shows restored presence of proteins indicating myelin reformation (shown in red) in the lumbar spinal cord of a mouse treated with miR-219 mimic after injury to its central nervous system. Researchers report March 27 in Developmental Cell treatment with the micro-RNA partially repaired damaged nerves and restored limb function in mice. Credit: Cincinnati Children's

    This image shows restored presence of proteins indicating myelin reformation (shown in red) in the lumbar spinal cord of a mouse treated with miR-219 mimic after injury to its central nervous system. Researchers report March 27 in Developmental Cell treatment with the micro-RNA partially repaired damaged nerves and restored limb function in mice. Credit: Cincinnati Children’s

    Scientists partially re-insulated ravaged nerves in mouse models of multiple sclerosis (MS) and restored limb mobility by treating the animals with a small non-coding RNA called a microRNA...

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    Scientists discover Mechanism that causes Cancer Cells to Self-Destruct

    March 27, 2017, Categories  Health/Medical, Biology/Biotechnology

    Aberrant spindles and impaired spindle poles in human cancer cells treated with the phenanthridine PJ34.

    Aberrant spindles and impaired spindle poles in human cancer cells treated with the phenanthridine PJ34. (A) Small aberrant spindles were identified by confocal microscopy in randomly scanned human breast cancer MDA-MB-231 cells incubated with PJ34 (20 μM, 27 h). Spindles were immunolabeled for HSET/kifC1 (green) bound to microtubules. Similarly immunolabeled spindles are not impaired in PJ34 treated normal human breast epithelial cells MCF10A. Bars indicate the spindle length measured by the scale bar (n = 20; 3 different experiments), 95% of the spindles in MDA-MB-231 cells were shorter, 60 ± 5% in size. (B) Upper panel: Impaired spindle poles were identified in randomly scanned fixed MDA-MB-231 cells treated with PJ34 (20 μM, 27 h)...

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