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    Category Health/Medical

    Ultrafast Detection of a Cancer Biomarker enabled by innovative Nanobiodevice

    March 8, 2017, Categories  Biology/Biotechnology, Health/Medical

    (A) An image of the nanobiodevice (left), an SEM image of the hybrid structure of nanopillars and nanoslits (middle), and the magnified SEM image (right). (B) Schematic of the hybrid structure of nanopillars and nanoslits around the cross injector. (C) Diagram showing the scheme of sample injection. Figure panels C-a to C-e are arranged by time in ascending order. Sample of nucleic acids and direction of electrophoretic migration are depicted in green diagonal and blue arrows, respectively. Suggested dominant mechanisms for each process are shown at the bottom.

    (A) An image of the nanobiodevice (left), an SEM image of the hybrid structure of nanopillars and nanoslits (middle), and the magnified SEM image (right). (B) Schematic of the hybrid structure of nanopillars and nanoslits around the cross injector. (C) Diagram showing the scheme of sample injection. Figure panels C-a to C-e are arranged by time in ascending order. Sample of nucleic acids and direction of electrophoretic migration are depicted in green diagonal and blue arrows, respectively. Suggested dominant mechanisms for each process are shown at the bottom.

    A nanobiodevice that can quickly and effectively separate microRNA from mixtures of nucleic acids has been developed...

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    Small molecules fighting Aging-related Diseases

    March 8, 2017, Categories  Health/Medical, Biology/Biotechnology

    One of the activating molecules synthesized by the research group binds to Sirtuin 6. The chemical name of the activator is “4-(pyridine-3-yl)-4,5-dihydropyrrolo[1,2-α]quinoxaline”. Illustration: Clemens Steegborn (free with attribution).

    One of the activating molecules synthesized by the research group binds to Sirtuin 6. The chemical name of the activator is “4-(pyridine-3-yl)-4,5-dihydropyrrolo[1,2-α]quinoxaline”. Illustration: Clemens Steegborn (free with attribution).

    For the first time molecules able to activate enzyme sirtuin 6 has been produced by an international research network led by Bayreuth Biochemist Prof. Dr. Clemens Steegborn. Furthermore, the scientists were able to reveal the structural basis of such processes. These findings will enable the development of drugs that might support the fight against aging-related diseases. Sirtuins are enzymes that fulfil a variety of regulatory functions in the body. In particular, they regulate energy metabolism and stress responses...

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    New Protein discovered in Aging, Cancer

    March 7, 2017, Categories  Health/Medical, Biology/Biotechnology

    ITGB3 (integrin β3) is regulated by the Polycomb protein CBX7 •β3 regulates senescence by activating TGF-β in a paracrine and autocrine fashion •β3 is highly expressed in OIS and induces senescence via ligand-independent pathway •There is a positive correlation between β3 levels and aging in different tissues

    ITGB3 (integrin β3) is regulated by the Polycomb protein CBX7 •β3 regulates senescence by activating TGF-β in a paracrine and autocrine fashion •β3 is highly expressed in OIS and induces senescence via ligand-independent pathway •There is a positive correlation between β3 levels and aging in different tissues

    A protein has been found to have a previously unknown role in the aging of cells, according to an early study by Queen Mary University of London (QMUL). The researchers hope that the findings could one day lead to new treatments for aging and early cancer. A number of ‘abnormal’ cells have previously been found in tissues derived from old patients and at the initial stages of cancer...

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    Boosting your own Defenses against Heart Disease

    March 7, 2017, Categories  Health/Medical, Biology/Biotechnology

    ATF6 is protective in the heart; it is expressed at high levels in the young heart, and low levels in the aged heart. Gene therapy studies that were done in the Glembotski lab at the SDSU Heart Institute have shown that restoring ATF6 in the aged mouse heart to levels in the young heart provides remarkable protection against heart disease, and could pave the way for development of this therapy for use in humans in the near future. Credit: Chris Glembotski

    ATF6 is protective in the heart; it is expressed at high levels in the young heart, and low levels in the aged heart. Gene therapy studies that were done in the Glembotski lab at the SDSU Heart Institute have shown that restoring ATF6 in the aged mouse heart to levels in the young heart provides remarkable protection against heart disease, and could pave the way for development of this therapy for use in humans in the near future. Credit: Chris Glembotski

    A protein found in the heart that is known to be involved in cellular stress responses in cancer cells is now believed to play a critical role in the ability of cardiac cells to combat heart disease and recover from a heart attack...

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