Category Health/Medical

FLP-7 and NPR-22 function as a fat regulatory neuroendocrine ligand-receptor pair in vivo.

Biologists at TSRI have identified a brain hormone that appears to trigger fat burning in the gut. Their findings in animal models could have implications for future pharmaceutical development. “This was basic science that unlocked an interesting mystery,” said TSRI Assistant Professor Supriya Srinivasan. Previous studies had shown that serotonin can drive fat loss. Yet no one was sure exactly how.

To answer that question, Srinivasan and her colleagues experimented with C. elegans, which are often used as model organisms in biology...

Vitamin A deficiency increased the production of plaques in the brains of mice.

Vitamin A deficiency could ‘program’ brain tissue. Biochemical reactions that cause Alzheimer’s disease could begin in the womb or just after birth if the fetus or newborn does not get enough vitamin A, according to new research from the University of British Columbia. These new findings, based on studies of genetically-engineered mice, also demonstrate that Vit A supplement given to newborns with low levels of vitamin A could be effective in slowing the degenerative brain disease.

“Our study clearly shows that marginal deficiency of vitamin A, even as early as in pregnancy, has a detrimental effect on brain development and has long-lasting effect that may facilitate Alzheimer’s disease in later life,” said Dr...

Diets high in vegetables, fruits, whole grains, fish and nuts have been shown to reduce inflammation

Anti-inflammatory diets (high in vegetables, fruits, fish, whole grains) could boost bone health and prevent fractures in some women, a new study suggests. Researchers examined data from the Women’s Health Initiative to compare levels of inflammatory elements in the diet to bone mineral density and fractures and found new associations between food and bone health.

Women with the least-inflammatory diets (based on a scoring system called the Dietary Inflammatory Index) lost less bone density during the 6-year follow-up period than their peers with the most-inflammatory diets. This was despite the fact that they started off with lower bone density overall...

Regulation of type I interferon responses

Scientists have discovered that a biological molecule important in cell growth (STAT3) is also critical in protecting us against infection – so much so that we would be unable to fight the common flu virus without it. Their discovery could pave the way to the development of new therapeutics charged with restoring our natural immunity to a whole spectrum of viruses that have evolved ‘roadblocks’ to the immune response. In a world of newly emerging viral infections such as SARS, ZIKA and Ebola, the importance of understanding how viruses target our immune system, and the need to develop new therapies to cure and protect us, has never been greater.

During any viral infection our cells produce Interferon, which essentially ‘interferes’ with the battle ...