Category Health/Medical

Survey of New York City Soil uncovers medicine-making microbes

Researchers in the Brady lab, postdoc Zachary Charlop-Powers, above, examine DNA from soil samples that might encode microbial molecules with interesting properties. Credit: Zach Veilleux/The Rockefeller University

Researchers in the Brady lab, postdoc Zachary Charlop-Powers, above, examine DNA from soil samples that might encode microbial molecules with interesting properties. Credit: Zach Veilleux/The Rockefeller University

In soil collected from city parks, Rockefeller Uni researchers dug up genetic evidence of bacteria capable of producing a wide range of compounds whose potent effects might be used as medicines. “By sequencing and analyzing genes within soil samples, we found the genetic instructions for making a wide range of natural products that have the potential to become treatments for various conditions, from cancer to bacterial or fungal infections, or that are already being used as drugs,” says Sean F...

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First-ever Capsule to Treat Hemophilia Developed

Illustration of the degradable system carrying treatment for hemophilia B. Credit: Cockrell School of Engineering

Illustration of the degradable system carrying treatment for hemophilia B. Credit: Cockrell School of Engineering

In the near future, hemophiliacs could be able to treat their disease by simply swallowing a capsule. Thanks to a breakthrough led by researchers in the Cockrell School of Engineering at The University of Texas at Austin, treatment for hemophilia can now be administered via a biodegradable system, a capsule, giving people affected by the hereditary bleeding disorder hope for a less expensive, less painful treatment option than conventional injections or infusions.

They designed the oral delivery system, which contains micro- and nanoparticles, to carry a protein therapy that treats hemophilia B. There are ~400,000 people worldwide with hemophilia A or B...

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Connection found between Memory Mechanisms, Resistance to Epilepsy

eEF2 pathways regulate cellular protein translation. (A) Activation of NMDA receptor enables Ca2+ to enter the cell. In the presence of Ca2+ and calmodulin (CaM) elongation factor 2 kinase (eEF2K) is activated, leading to increased phosphorylation (and inhibition) of elongation factor 2 (eEF2) and overall decreased protein translation. (B) Protein kinase A (PKA) can phosphorylate eEF2K, thereby reducing eEF2K dependency on calmodulin and Ca2+, making eEF2K more active. In the presence of calmodulin and Ca2+, eEF2K inhibits eEF2 activity by phosphorylation, which results in attenuated cap-dependent translation, but evidently, can increase translation of other proteins like Arc, BDNF, and, αCAMKII. (C) Possible mTOR pathway for translation regulation. mTOR can regulate eEF2 phosphorylation and, consequently, elongation by phosphorylation of S6K1 for example, which can then inhibit eEF2K activity by phosphorylation (different phosphorylation site from PKA), leading to decreased phospho-eEF2 levels and increased elongation rate.

eEF2 pathways regulate cellular protein translation

A new study exposes a new biological mechanism that, on the one hand, damages a very specific type of memory, but at the same time provides resistance to epilepsy. Research student Elham Taha from the laboratory of Prof. Kobi Rosenblum explains: “In both healthy and sick brains, the relationship between the activities of the nerve cells that cause the transfer of information and activities delaying the transmission of information is extremely important. We know that damage to this relationship forms the basis of various brain diseases, such as neuro-developmental diseases and epilepsy. The aim of our study was to isolate molecular components that serve the creation of long-term memories...

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Mouth Cancer Rates Soar over 20 years

oral cancer exam

With Oral Cancer, Early Detection Is Key

A new Cancer Research UK analysis reveals that rates of mouth (oral) cancer have jumped by 68% in the UK over the last 20 years. The figures – released during Mouth Cancer Action Month – reveal the cancer is on the rise for men and women, young and old, climbing from 8 to 13 cases per 100,000 people over the last two decades. For men under 50, the rate has jumped by 67% in the last 20 years – going up from around 340 cases to around 640 cases each year.

For men 50+ years, rates have increased by 59% climbing from around 2,100 cases to around 4,400 cases annually. Oral cancer is more common in men, but there have been similar increases women...

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