Category Health/Medical

Aerobic exercise preserves brain volume and improves cognitive function

Using a new MRI technique, researchers found adults with mild cognitive impairment (MCI) who exercised 4 times a week over a 6-month period experienced an increase in brain volume in specific, or local, areas of the brain, but adults who participated in aerobic exercise experienced greater gains than those who just stretched. The study included 35 adults with MCI participating in a randomized, controlled trial of exercise intervention. Individuals with MCI are at risk of developing Alzheimer’s disease (AD) which affects >5 million Americans today.

The participants were divided into two groups...

Researchers have developed a specialized type of glowing metal organic framework, or LMOF (molecular structure at center), that is designed to detect and remove heavy-metal toxins from water. At upper left, mercury (Hg) is taken in by the LMOF. The graph at lower left shows how the LMOF’s fluorescence is turned off as it binds up the mercury. Its properties make this LMOF useful for both detecting and trapping heavy-metal toxins. Credit: Rutgers University

X-ray study explores atomic structure of tiny traps for heavy metals. Tiny, glowing crystals that detect and capture heavy-metal toxins such as lead and mercury could prove to be a powerful new tool in locating and cleaning up contaminated water sources...

Image1: A platypus. The same hormone produced in the gut of the platypus to regulate blood glucose is also produced in their venom, researchers have found – and that hormone could be used in possible type 2 diabetes treatments. Image2: An echidna. The same hormone produced in the gut of the echidna to regulate blood glucose is also produced in their venom, researchers have found – and that hormone could be used in possible type 2 diabetes treatments.

Australian researchers have discovered remarkable evolutionary changes to insulin regulation in two of the nation’s most iconic native animal species – the platypus and echidna – which could pave the way for new treatments for type 2 diabetes in humans...

Bmal1/Clock complex activates transcription of genes containing E-box sequences in their promoters. Among these are Per1/2 and Cry1/2, which following dimerization can inhibit the activity of the Bmal1/Clock complex. Rev-Erb and Ror provide an additional stabilizing loop to fine-tune the expression of Bmal1. In addition to E-boxes, other clock regulatory elements (such as ROREs and D-boxes) are commonly found in the promoters of CCGs.

Disruptions of daily rhythms of the body’s master internal clock provide insight into the role of the brain’s internal time keeping system in the development of mood disorders, such as bipolar disorder and major depressive disorder MDD, which have been associated with disturbed daily (circadian) rhythms...