Category Health/Medical

Highlights SIP is a new protein phosphatase 2A-containing protein complex SIP is essential for the asymmetric localization of SIN components to the SPB SIP is required for the SPB localization of the SIN inhibitor Byr4p SIP promotes dephosphorylation of the SIN scaffold protein Cdc11p

A naturally occurring predatory bacterium is able to work with the immune system to clear multi-drug resistant Shigella infections in zebrafish. It is the first time the predatory bacterium Bdellovibrio bacteriovorus has been successfully used as an injected anti-bacterial therapy and represents an important step in the fight against drug-resistant infections, or ‘superbugs’.

Shigella infection is responsible for over 160 million illnesses and over 1 million deaths every year – and is a common cause of ‘trave...

Synovial Fibroblasts (SFs)  are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint

A study reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint.

A team from University of Birmingham’s Institute of Inflammation and Ageing identified 2 distinct types of SF within the synovial membrane...

The attached image shows microscope images of the engineered cells (nuclei in blue) with HIF-1 visualized (in red). In the left hand panel, cells are in hypoxia but no doxyxyclin is present, therefore HIF-1 remains active (red dots). In the right hand panel, the cells are grown in hypoxia and in the presence of doxyxyxlin, therefore the cyclic peptide inhibitor is produced and HIF-1 is inhibited, as demonstrated by the absence of the red dots. Credit: Image courtesy of University of Southampton

Researchers at the University of Southampton have engineered cells with a ‘built-in genetic circuit’ that produces a molecule that inhibits the ability of tumors to survive and grow in their low oxygen environment...

Stage IV is when the invasive breast cancer has spread beyond the breast to nearby lymph nodes to other organs, such as the lungs, skin, bones, liver, and the brain, This may also be called, advanced stage or mechanistic stage of cancer, IV cancer a be a reoccurrence of previous cancer that has spread to other parts of the body.

A team from Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has found that controlling the levels of the TIP60 protein, which is a tumor suppressor, could potentially prevent the spread of breast cancer cells. Specifically, TIP60 interacts with two other proteins DNMT1 and SNAIL2, to inhibit the spread of cancer cells...