Category Health/Medical

Cervical cancer Signs & Symptoms, Prevention & Rx

Johns Hopkins Medicine specialists report they have developed a urine test for the likely emergence of cervical cancer that is highly accurate compared to other tests based on genetic markers derived directly from cervical tissue. The new urine test, they say, is different because it analyzes not only multiple sources of human cellular DNA altered by precancerous changes, but also DNA from HPV that is sexually transmitted and causes virtually all cases of the disease.

In a proof-of-concept study the investigators say their genetic markers test showed a “sensitivity” or accuracy rate of 90...

Highlights • Loss of CRY2 stabilizes c-MYC and enhances cellular transformation • CRY2 can function as a co-factor for the SCF substrate adaptor FBXL3 • c-MYC phosphorylated on threonine 58 (T58) interacts with CRY2 • SCFFBXL3+CRY2 promotes the ubiquitylation and turnover of c-MYC

TSRI researchers find an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth. The new research suggests disruptions in circadian rhythms might leave levels of an important cancer-linked protein, cMYC unchecked. “This appears to have big implications for the connection between circadian rhythms and cancer,” said TSRI biologist Katja Lamia, senior author of the study.

There is growing evidence that shift work and frequent jet lag can raise a person’s risk of ...

Ceftriaxone partially restores glutamate dynamic deficits around Aβ deposits.

New research from the Djavad Mowafaghian Centre for Brain Health at UBC has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer’s disease. The findings, published this week in Nature Communications, demonstrate a possible target and a potential drug treatment to reduce damage to the brain that occurs in the early stages of Alzheimer’s disease. Using Ceftriaxone, an FDA-approved antibiotic used to treat bacterial infections, researchers were able to reduce synaptic disruption and clear the lines of neuronal communication in mice.

Amyloid plaques of -amyloid deposits develop in brain regions of patients with Alzheimer’s disease, These plaques are link...

Increased Activation in Control Regions in Older Adults Tested at a Peak Time of Day.

As you age, you may find it more difficult to focus on certain tasks. But while distractions can be frustrating, they may not be as bad as we think. Researchers at the University of Toronto and Harvard University suggest that there may be some benefits to reduced focus, especially >50yo. Using behavioral studies and neuroimaging, they discuss how being easily distracted can help adults with, eg. problem solving and learning new information.

“Different types of tasks benefit from a more broad focus of attention, and this is usually seen in tasks that involve thinking creatively or using information that was previously irrelevant,” says Tarek Amer, Ph.D.

When people have high cognitive control, they are abl...