Category Health/Medical

These 11 Genes may help us Better Understand Forever Chemicals’ Effects on the Brain

A blue gloved hand places a small bottle of liquid into a laboratory machine.
A study led by the labs of University at Buffalo chemistry professors G. Ekin Atilla-Gokcumen and Diana Aga has uncovered some molecular clues about the neurotoxic effects of  per- and polyfluorinated alkyl substances, better known as forever chemicals. Photo: Meredith Forrest Kulwicki/University at Buffalo

Molecular clues about the neurotoxic effects of PFAS. A new study has identified 11 genes that may hold the key to understanding the brain’s response to these pervasive chemicals commonly found in everyday items.

Per- and polyfluorinated alkyl substances (PFAS) earn their “forever chemical” moniker by persisting in water, soil and even the human brain.

This unique ability to cross the blood-brain barrier and accumulate in brain tissue makes PFAS particularly concerning, but t...

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Mediterranean Diet Linked to Improved Memory via Gut Bacteria Changes

Mediterranean diet
The Mediterranean diet focuses on fruits, vegetables, whole grains, olive oil, fish and legumes. Photo by Shutterstock

A new Tulane University study suggests the Mediterranean diet’s brain-boosting benefits may work by changing the balance of bacteria in the gut.

In a study published in Gut Microbes Reports, researchers at Tulane University School of Medicine found that subjects following a Mediterranean diet developed distinctly different gut bacteria patterns compared to those eating a typical Western diet. These bacterial changes correlated with better memory and cognitive performance.

“We’ve known that what we eat affects brain function, but this study explores how that could be happening,” said lead author Rebecca Solch-Ottaiano, Ph.D...

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Gene Therapy Research offers hope for people with Chronic Kidney Disease

Gene therapy research offers hope for people with chronic kidney disease
A mechanistic model of AAV9 and AAV-KP1-mediated renal transduction. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54475-9

Researchers are making strides in improving gene therapies for genetic diseases, particularly chronic kidney disease, using adeno-associated virus, or AAV, vectors. While AAV-based treatments have shown promise, delivering these therapies effectively to the kidneys has remained a challenge—until now.

There are many different types of AAV capsids—the protein shells of virus particles—that have been used to deliver genes to cells, each with unique effects...

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Microplastics found in Multiple Human Organ Tissues Correlated with Lesions

Microplastics found in multiple human organ tissues correlated with lesions
Graphical abstract. Credit: TrAC Trends in Analytical Chemistry (2024). DOI: 10.1016/j.trac.2024.118114

Research led by Zhejiang Agriculture and Forestry University in China has performed a metadata investigation into the presence of microplastics in humans. They report a concerning relationship between micro and nanoplastic (MNP) concentrations in damaged tissues and links with multiple health conditions.

Plastic usage soared from 1.5 million metric tons in the 1950s to nearly 390.7 million in 2021. With the increased use in consumer products came elevated microscopic plastic pollution circulating in soil and waterways, eventually accumulating in the environment, food webs and human tissues.

Consistent methods to pinpoint and quantify MNPs in human tissues are lacking...

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