Category Health/Medical

Lack of antinociceptive tolerance of YHS (200 mg/kg) in the tail flick assay (n = 7–8).

Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms. In a new study, Olivier Civelli, professor and chair of pharmacology at the University of California, Irvine et al show how YHS effectively treats different forms of pain. Most notably it can reduce chronic neuropathic pain which is poorly treated with common medicines. They also show that YHS seems to not lose its potency over time, as happens with many analgesics.

The researchers analyzed YHS pain relief properties in mouse tests that monitor acute, pe...

A patient’s foot is tested for neuropathy. Credit: Northwestern University

For the 25% of type-2 diabetes patients who suffer from numbness and extreme nerve pain in their feet, a new dermatological treatment being tested by Northwestern Medicine scientists could potentially help prevent and maybe even reverse the neuropathy. Depleting a chemical called GM3 through genetic modification prevented the development of neuropathy in obese diabetic mice.

The researchers are now applying a gene therapy ointment to deplete GM3 and GM3 synthase, which is the enzyme that makes GM3. The hope is that this GM3-depleting ointment, applied just to the footpad of diabetic mice, will prevent or, even better, reverse the existing neuropathy...

Low-temperature plasma generator. Left: (1) gas flow, (2) SHF electrode, (3) plasma jet, (4) power source, (5) ground electrode. Right: (6) metal tube, (7) power, (8) plasma jet. Credit: MIPT

Scientists have found that treating cells with cold plasma leads to their regeneration, rejuvenation. This result can be used to develop a plasma therapy program for patients with non-healing wounds. Non-healing wounds make it more difficult to provide effective treatment to patients and are therefore a serious problem faced by doctors. These wounds can be caused by damage to blood vessels in the case of diabetes, failure of the immune system resulting from an HIV infection or cancers, or slow cell division in elderly people.

Cold atmospheric-pressure plasma refers to a partially ionized gas (the prop...

This is an illustration depicting EKG readings before, during and after the use of light — optogenetic deffibtillation — to restore a normal heartbeat to an arrhythmic heart. Credit: Patrick M. Boyle/Johns Hopkins University

Using high-tech human heart models and mouse experiments, scientists at Johns Hopkins and Germany’s University of Bonn have shown that beams of light could replace electric shocks in patients reeling from a deadly heart rhythm disorder. The findings could pave the way for a new type of implantable defibrillators. Current devices deliver pulses of electricity that are extremely painful and can damage heart tissue. Light-based treatment should provide a safer and gentler remedy for patients at high risk of arrhythmia that can cause sudden cardiac death within minutes.

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