Category Health/Medical

Neurons form Synapse Clusters

The synapses of pyramid cells in the cerebral cortex form functional groups. Some of the related synapses are shown in green in the reconstruction. Credit: MPI of Neurobiology / Scheuss

The synapses of pyramid cells in the cerebral cortex form functional groups. Some of the related synapses are shown in green in the reconstruction. Credit: MPI of Neurobiology / Scheuss

The contact points of cells in the cerebral cortex form functional groups. The cerebral cortex resembles a vast switchboard. Countless lines carrying information about the environment, for example from the sensory organs, converge in the cerebral cortex. In order to direct the flow of data into meaningful pathways, the individual pyramidal cells of the cerebral cortex act like miniature switchboard operators. Each cell receives information from several thousand lines. Scientists have shown for the first time that synapses between specific neuron types are clustered in groups on the target neuron...

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Protein found to Bolster Growth of Damaged Muscle tissue

Activating [beta]1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

Activating β1-integrin in mdx mice ameliorates dystrophic pathology and restores muscle strength.

This could potentially contribute to Rx for muscle degeneration caused by old age and diseases such as muscular dystrophy. A particular type of protein called integrin is present on the stem cell surface and used by stem cells to interact with, or “sense” their surroundings. How stem cells sense their surroundings, also known as the stem cell “niche,” affects how they live and last for regeneration. The presence of the protein β1-integrin was shown to help promote the transformation of those undifferentiated stem cells into muscle after the tissue has degraded, and improve regenerated muscle fiber growth as much as 50%.

The experiment shows that β1-integrin – one of 28 types of integrin – mai...

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Scientists Pinpoint a Neural Center of Resilience

Dynamic neural activity during stress signals resilient coping

Dynamic neural activity during stress signals resilient coping

Why some people handle stress better than others is a question that has fascinated scientists for decades. Now a Yale-led team reports that flexible brain activity in a particular area of the brain may predict resilience. Conversely, its absence can help pinpoint those most at risk for binge drinking, emotional eating, and angry outbursts, according to a study published the week of July 18 in the journal Proceedings of the National Academy of Sciences.

30 research participants were given fMRI scans while exposed to either highly threatening, violent, and stressful images and to neutral, non-stressful images for 6 minutes each. The scientists found 3 distinct patterns of response to stress...

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New Link between Periodontal and Cerebrovascular Diseases

Lacunar infarcts are the result of obstructions of blood flow in the small, deep arteries in the brain

Lacunar infarcts are the result of obstructions of blood flow in the small, deep arteries in the brain

A new study has revealed a relationship between chronic periodontitis and lacunar infarct, two common diseases in the elderly. Chronic periodontitis is an inflammatory disease of the gums, whereas lacunar infarct is a type of cerebral small vessel disease that can lead to a stroke.

Additional research is needed to understand this link. It is hypothesized that periodontitis leads to systemic inflammation and, as a result, the health of the blood vessels could be affected. On the other hand, chronic periodontitis and lacunar infarct may share common vascular risk factors such as hypertension, diabetes, and high cholesterol.

Periodontitis

Periodontitis

“We observed that people diagnosed with periodontal d...

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