
Researchers working on inhalable ibuprofen to treat cystic fibrosis
In cystic fibrosis, high dose ibuprofen helps slow decline of lung function, a disease caused by having two ‘bad’ copies of a gene that codes for a protein important in fluid secretion. Improved lung function is important, given that most people diagnosed die by their early 50s, usually due to chronic lung infections caused by their inability to move particles, including bacteria, up and out of the lungs. The downside is that ibuprofen doses that high, when taken routinely, can result in gastrointestinal (GI) bleeding and – when combined with the antibiotics that these patients often have to take for their recurring lung infections – acute kidney injury...
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![A prototype closed-loop system. (a) A prototype closed-loop system comprises a continuous glucose monitor (CGM) sensor and receiver, an insulin pump, and a mobile phone running a control algorithm (potentially the algorithm may be located on the insulin pump obviating the need for a hand-held controller/mobile phone device). (b) A photo of a participant (obtained with consent) using the closed-loop system during a home study [8]](https://static-content.springer.com/image/art%3A10.1007%2Fs00125-016-4022-4/MediaObjects/125_2016_4022_Fig1_HTML.gif)


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