Category Health/Medical

Potential Drug Target identified for Zika, Similar Viruses, eg dengue and West Nile

A transmission electron micrograph image of the Zika virus. Credit: Centers for Disease Control and Prevention

A transmission electron micrograph image of the Zika virus. Credit: Centers for Disease Control and Prevention

Scientists potentially have found a way to disrupt Zika and similar viruses from spreading in the body. A team at Washington University School of Medicine in St. Louis has identified a single gene pathway that is vital for Zika and other flaviviruses to spread infection between cells. Further, they showed that shutting down a single gene in this pathway – in both human and insect cells – does not negatively affect the cells themselves and renders flaviviruses unable to leave the infected cell, curbing the spread of infection.

Michael Diamond, MD, PhD, the Herbert S...

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A deadly delivery for Triple-Negative Breast Cancer Tumors

Live cell imaging shows fluorescently-labelled targeted ZnO nanoparticles (green) dissolving to release zinc ions (blue) within the intracellular environment of triple-negative breast cancer cells, activating cell death pathways (red).

Live cell imaging shows fluorescently labeled targeted ZnO nanoparticles (green) dissolving to release zinc ions (blue) within the intracellular environment of triple-negative breast cancer cells, activating cell death pathways (red). © 2016 KAUST

Zinc oxide (ZnO) nanoparticles may help destroy difficult-to-treat triple-negative breast cancer tumors. Breast tumors that are so-called triple-negative are largely resistant to existing cancer drugs, giving patients an especially poor prognosis. Researchers at King Abdullah University of Science and Technology (KAUST), Saudi Arabia, and collaborators are now exploring a potential therapeutic option for such tumors that is based on the tumor-specific effects of zinc oxide (ZnO) nanoparticles.

Previous studies have shown ZnO treatment can kill c...

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How Fat becomes Lethal, even without Weight Gain

a small, normal liver next to an enlarged, fatty liver

The livers of a normal mouse (left) and a mouse whose liver cells lack Cpt2 (right) after eating a high fat diet. Courtesy of Cell Press

Study in mice shows important role of liver in balancing fats and sugars. Sugar in the form of blood glucose provides essential energy for cells. When its usual dietary source – carbohydrates – is scarce, the liver can produce it with the aid of fat. But new research from Johns Hopkins now adds to evidence that other tissues can step in to make glucose when the liver’s ability is impaired, and that the breakdown of fats in the liver is essential to protect it from a lethal onslaught of fat...

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Threading the Way to Touch-Sensitive Robots

The twisted smart threads developed by KAUST researchers can be woven into pressure-sensitive ‘electronic skin’ fabrics for use in novel clothing, robots or medical prosthetics. Credit: © 2016 KAUST

The twisted smart threads developed by KAUST researchers can be woven into pressure-sensitive ‘electronic skin’ fabrics for use in novel clothing, robots or medical prosthetics. Credit: © 2016 KAUST

Smart threads can be woven into pressure-sensitive electronic skin for robots or medical prosthetics. Fabrics containing flexible electronics are appearing clothes with in-built screens and solar panels. These fabrics can act as electronic skins that can sense their surroundings and could have applications in robotics and prosthetic medicine. Researchers at King Abdullah University of Science and Technology (KAUST), Saudi Arabia, have now developed smart threads that detect the strength and location of pressures exerted on them.

Most flexible sensors function by detecting changes in the el...

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