Category Health/Medical

Before the delivery of the neurotoxin (left) the SCN oscillate in a synchronized pattern. After the delivery of the neurotoxin (right), neurons in the SCN oscillate randomly. Credit: Image courtesy of the Doyle Lab

For the 1st time it has been shown how neurons in the SCN are connected to each other, shedding light on this vital area of the brain. Understanding this structure – and how it responds to disruption – is important for tackling illnesses like diabetes and PTSD. The scientists have also found that disruption to these rhythms such as shifts in work schedules or blue light exposure at night can negatively impact overall health...

After treatment with riluzole, the brains of old rats showed more of a transporter molecule that removes excess glutamate, (green fluorescence, right) as compared to untreated rats (left). Credit: Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at The Rockefeller University/Molecular Psychiatry

In new research a drug, riluzole, is capable of reversing key genetic changes associated with these conditions. “In aging and Alzheimer’s, the chemical signal glutamate can accumulate between neurons, damaging the circuitry,” Pereira says. “When we treated rats with riluzole, we saw a suite of changes. Perhaps most significantly, expression of molecules responsible for clearing excess glutamate returned to more youthful levels...

Furukawa and colleagues have obtained images showing for the first time how different domains of the NMDA receptor move when the receptor is in active, non-active, and inhibited states. Understanding how NMDA receptors activate is critical in designing novel therapeutic compounds for potential use in schizophrenia, depression and other disorders. Credit: Furukawa Lab, CSHL

Researchers have obtained images of the NMDA receptor in active, non-active, and inhibited states. Understanding how NMDA receptors activate is critical in designing novel therapeutic compounds for schizophrenia, depression, Alzheimer’s and other illnesses...

A new Salk study is the first to closely follow the development of new neurons in the adult brain, giving insight into neurodevelopmental disorders such as autism and schizophrenia. By genetically engineering new neurons to fluoresce green, researchers were able to see when the new cells grew and branched surrounded by other cell nuclei (blue) in the brain. Credit: Salk Institute

A new study is first to closely follow development of new neurons in the adult brain, giving potential new insight into neurodevelopmental disorders such as autism and schizophrenia. New brain cells began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. “We were surprised by the extent of the pruning we saw,” says Prof. Rusty Gage.

While most o...