Category Health/Medical

Finding Sleep’s Sweet Spot

A new study finds a link between adequate sleep, earlier bedtimes and heart-healthy behavior. Credit: University of Delaware/Jeffrey C. Chase

A new study finds a link between adequate sleep, earlier bedtimes and heart-healthy behavior. Credit: University of Delaware/Jeffrey C. Chase

Study connects Early Bedtime and ‘Adequate’ sleep with Heart Healthy choices. Early-to-bed, early-to-rise approach aligns much better with cardiovascular health. Sleep deficits and poor-quality sleep have been linked to obesity and a myriad of health problems, but this study shows that when it comes to promoting healthy hearts, it’s not a matter of getting more sleep. It’s a matter of getting adequate sleep at optimal times. Doing that seems to reduce the kind of behaviors – smoking, sedentary lifestyles and poor dietary choices – that put hearts in harm’s way.

The study examined the duration and approximate timing of sleep to see what patterns might...

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Mice Flown in Space show Nascent Liver damage

Space shuttle Atlantis is photographed from the International Space Station as it flies over the Bahamas prior to docking with the station (2011). Credit: NASA

Space shuttle Atlantis is photographed from the International Space Station as it flies over the Bahamas prior to docking with the station (2011). Credit: NASA

In a discovery with implications for long-term spaceflight and future missions to Mars, a researcher at the University of Colorado Anschutz Medical Campus has found that mice flown aboard the space shuttle Atlantis returned to Earth with early signs of liver disease. “Prior to this study we really didn’t have much information on the impact of spaceflight on the liver,” said A/Prof Karen Jonscher. “We knew that astronauts often returned with diabetes-like symptoms but they usually resolved quickly.”

The mice studied spent 13.5 days aboard the space shuttle...

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A New Player Revealed in Nerve Growth Process

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.

A protein previously known for its role in kidney function, adaptor protein CD2AP, also plays a significant role in the nervous system, and is associated with a type of neural growth known as collateral sprouting. CD2AP orchestrates a complex arrangement of other proteins that controls the branching of nerve axons, the tendrils reaching out from the nerve cell to connect to other nerve cells, skin and organs. This nerve growth occurs in uninjured nerve cells as they extend their reach and create new connections.

Harrison said. “There are a whole bunch of proteins that it could bring together, but it only brings together the correct proteins to create the correct response...

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Early Abnormalities of Alzheimer’s disease: It takes 2 proteins to tango

Synergistic effect between [18F]florbetapir SUVR and CSF p-tau drives [18F]FDG uptake decline in limbic regions. Statistical parametric maps, after correcting for multiple comparisons (false discovery rate corrected at P<0.001), overlaid in a structural MRI scan, reveal areas in which 24-month [18F]FDG uptake decline occurs as a function of the synergistic interaction between baseline [18F]florbetapir SUVR and CSF p-tau measurements. Significant interactive effects were observed in the basal and mesial temporal, orbitofrontal, and anterior and posterior cingulate cortices. The analysis was corrected for age, gender and APOE ε4 status. CSF, cerebrospinal fluid; [18F]FDG, [18F]fluorodeoxyglucose; MRI, magnetic resonance imaging; p-tau, phosphorylated tau; SUVR, standardized uptake value ratio.

Synergistic effect between [18F]florbetapir SUVR and CSF p-tau drives [18F]FDG uptake decline in limbic regions. Statistical parametric maps, after correcting for multiple comparisons (false discovery rate corrected at P<0.001), overlaid in a structural MRI scan, reveal areas in which 24-month [18F]FDG uptake decline occurs as a function of the synergistic interaction between baseline [18F]florbetapir SUVR and CSF p-tau measurements. Significant interactive effects were observed in the basal and mesial temporal, orbitofrontal, and anterior and posterior cingulate cortices. The analysis was corrected for age, gender and APOE ε4 status...

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