Category Health/Medical

Engineering T cells to treat pancreatic cancer Researchers hope to have a human version of the T cell in clinical trials this year

Hingorani, a pancreatic cancer specialist, teamed up with Fred Hutch immunotherapy experts Drs. Phil Greenberg and Ingunn Stromnes in successful efforts to breach the cancer’s physical and immunological walls using immunotherapy, a type of treatment that harnesses or refines the body’s own immune system with T-cells engineered to recognize and destroy cancer cells.

Specifically, Hingorani’s team created T cells with a high ffinity to a “relatively” tumor-specific antigen. Why relatively? Notoriously difficult pancreatic tumor cells don’t produce many unique proteins that allow for completely tumor-specific T cells...

Black Novacast. Credit: Image courtesy of Investigación y Desarrollo

NovaCast is a device that prevents infections, ulcers and even amputation of limbs, is 10X lighter than the traditional material and allows a good ventilation. The use of plaster splints for the rehabilitation of bones can cause infections, ulcers and even amputations because their shape prevents proper medical inspection, sweat accumulates and generates little ventilation. To avoid these problems, a group of young graduates from the National University of Mexico (UNAM) created Mediprint, a Mexican startup that manufactures this medical devices to measure, using 3D printing devices.

“The material that conventional splints are made of is a highly hygroscopic plaster, meaning it absorbs sweat and causes the bacteria to pro...

Marijuana plant (stock image). Evidence of a compromised dopamine system has been found in heavy users of marijuana. Credit: © Vasily Merkushev / Fotolia

Evidence of a compromised dopamine system has been found in heavy users of marijuana. Effect similar to other addictions. Lower dopamine release was found in the striatum – involved in working memory, impulsive behavior, and attention. Previous studies have shown that addiction to other drugs of abuse, such as cocaine and heroin, have similar effects on dopamine release, but such evidence for cannabis was missing until now.

“In light of the more widespread acceptance and use of marijuana, especially by young people, we believe it is important to look more closely at the potentially addictive effects of cannabis on key regions of the brai...

New findings indicate that a previously thought harmful inflammation in the brain after a stroke might actually support self-healing. Photo: MostPhotos Published: 15/04/2016

After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair. “This is in total contrast to our previous beliefs,” says Professor Zaal Kokaia from Lund University in Sweden. It may lead to new ways of treating stroke in the future.

When stroke occurs, the nerve cells in the damaged area of the brain die, causing an inflammation that attracts cells from the immune syste...