Category Health/Medical

Effects of Alcohol, Methamphetamine, and Marijuana exposure on the Placenta

Sections of amnion with hematoxylin and eosin stains demonstrating meconium-related findings (original magnification ×40). (A) Normal amniotic epithelium (e); (B) vacuolated amniotic epithelial cells with pale vacuoles (v) and meconium-laden macrophages (m) below the basement membrane; (C) proliferation (p) of amniotic epithelial cells, demonstrated by numerous dark nuclei.

Sections of amnion with hematoxylin and eosin stains demonstrating meconium-related findings (original magnification ×40). (A) Normal amniotic epithelium (e); (B) vacuolated amniotic epithelial cells with pale vacuoles (v) and meconium-laden macrophages (m) below the basement membrane; (C) proliferation (p) of amniotic epithelial cells, demonstrated by numerous dark nuclei.

In the US, prenatal alcohol exposure (PAE) is the most common preventable cause of developmental delay. Animal studies have shown some of the adverse effects of PAE on placental development, but few studies have examined these effects in humans. This is the first study to examine the effects of prenatal exposure to methamphetamine, marijuana, and cigarette smoking on human placental development.

Researchers collected p...

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Targeting Gut Microbiome to fight Heart Disease

Carnitine, Choline, Cancer and Cholesterol: The TMAO Connection and how Resveratrol could be anti-atherosclerotic

Image: Carnitine, Choline, Cancer and Cholesterol: The TMAO Connection and how Resveratrol could be anti-atherosclerotic . NB. The concentration of TMAO in blood increases after consuming foods containing carnitine or lecithin if the bacteria that convert those substances to TMAO are present in the gut. High concentrations of carnitine are found in red meat, some energy drinks, and some dietary supplements; lecithin is found in soy, eggs, as an ingredient in processed food and is sold as a dietary supplement.

Resveratrol, found in red wine etc reduces the risk of heart disease by changing the gut microbiome, according to a new study by researchers from China...

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New tool enables scientists to interpret ‘Dark Matter’ DNA

Ratio of the CTCF and RAD21 ChIP-seq signals occurring within interacting enhancers and non-interacting enhancers, anchored at peaks for CTCF, RAD21, and the transcription factors CUX1 and HCFC1 for the K562 cell line.

Ratio of the CTCF and RAD21 ChIP-seq signals occurring within interacting enhancers and non-interacting enhancers, anchored at peaks for CTCF, RAD21, and the transcription factors CUX1 and HCFC1 for the K562 cell line.

Breakthrough technology opens the door to identifying new drug targets that could treat many genetic diseases. Scientists at the Gladstone Institutes have invented a new way to read and interpret the human genome. The computational method, TargetFinder, can predict where non-coding DNA-the DNA that does not code for proteins – interacts with genes. This technology helps researchers connect mutations in the so-called genomic “dark matter” with the genes they affect, potentially revealing new therapeutic targets for genetic disorders. Influence of features by region.

(a,b) Fe...

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‘Key’ to Recognizing, Immunizing Herpes/Common Cold A critical step discovered

S6K1 and S6K2 are required for Ad-induced activation of IRF3.

S6K1 and S6K2 are required for Ad-induced activation of IRF3.

Researchers at McMaster University have discovered a critical step in the immune system’s recognition of DNA viruses. It’s a key finding, they say, that could lead to vaccinations for herpes, the common cold or even cancer. A protein, previously known to be involved in metabolism, is critical for the detection of the viruses.

“We have identified an important step in the detection of DNA viruses by the immune system, and have shown that this is absolutely crucial in the response to a vaccine against these infections. If the key immune system component identified in these studies is not triggered, then vaccination fails” said Prof. Lichty.

Wan says this study could have further impact on a number of serious conditions and illnesse...

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