Category Health/Medical

Research discoveries by Bali Pulendran (seated) and colleagues point to possible new treatment strategies for inflammatory bowel diseases and autoimmune diseases in humans. Credit: Image courtesy of Emory Health Sciences

Intestinal inflammation in mice can be dampened by subjecting them briefly to a diet restricted in amino acids. The findings, made by Bali Pulendran and colleagues at Emory University, highlight an ancient connection between cellular mechanisms to sense nutrient availability and control of inflammation. They also suggest that a low protein diet – or drugs that mimic its effects on immune cells – could be tools for the treatment of inflammatory bowel diseases, such as Crohn’s disease or ulcerative colitis.

This protective effect was shown to be mediated by molecule GCN2, wh...

This is an infographic of how the implanted capsule releases antibodies to the brain. Credit: Patrick Aebischer (EPFL)

The lab of Patrick Aebischer at EPFL has developed a bioactive capsule containing cells that have been genetically engineered to produce antibodies against amyloid-β. The capsule is implanted in the tissue under the skin, and over time the cells produce and release a steady flow of antibodies into the bloodstream, from where they cross over into the brain to target the amyloid-β plaques.

To be most effective, this treatment has to be given as early as possible, before the first signs of cognitive decline. But this requires repeated vaccine injections, which can cause side effects...

A haploid cell with 23 chromosomes (left), and a diploid cell with 46 chromosomes (right). Credit: Columbia University Medical Center/Hebrew University

The stem cell carries a single copy of the human genome, instead of the two copies typically found in normal stem cells. These are the first human cells that are known to be capable of cell division with just 1 copy of the parent cell’s genome. Since the stem cells were a genetic match to the egg cell donor, they could also be used to develop cell-based therapies for diseases such as blindness, diabetes, or other conditions in which genetically identical cells offer a therapeutic advantage. Because their genetic content is equivalent to germ cells, they might also be useful for reproductive purposes.

Previous efforts to generate embryonic s...

Engram cell in AD mouse — This image depicts a single memory engram cell (green) in the hippocampal dentate gyrus (DG) region of a mouse model of early Alzheimer’s disease. To optically manipulate specific connections to these engram cells, a blue light-sensitive protein oChIEF was expressed in an upstream brain region, i.e., medial entorhinal cortical inputs (red) to the DG. The majority of DG granule cells were not active during engram labeling (blue, non-engram cells). Credit: Image courtesy of RIKEN

The rescue of memories, which changed both the structure of neurons as well as the behavior of mice, was achieved using optogenetics, a method for manipulating genetically tagged cells with precise bursts of light...