Category Health/Medical

Ratio of the CTCF and RAD21 ChIP-seq signals occurring within interacting enhancers and non-interacting enhancers, anchored at peaks for CTCF, RAD21, and the transcription factors CUX1 and HCFC1 for the K562 cell line.

Breakthrough technology opens the door to identifying new drug targets that could treat many genetic diseases. Scientists at the Gladstone Institutes have invented a new way to read and interpret the human genome. The computational method, TargetFinder, can predict where non-coding DNA-the DNA that does not code for proteins – interacts with genes. This technology helps researchers connect mutations in the so-called genomic “dark matter” with the genes they affect, potentially revealing new therapeutic targets for genetic disorders. Influence of features by region.

S6K1 and S6K2 are required for Ad-induced activation of IRF3.

Researchers at McMaster University have discovered a critical step in the immune system’s recognition of DNA viruses. It’s a key finding, they say, that could lead to vaccinations for herpes, the common cold or even cancer. A protein, previously known to be involved in metabolism, is critical for the detection of the viruses.

“We have identified an important step in the detection of DNA viruses by the immune system, and have shown that this is absolutely crucial in the response to a vaccine against these infections. If the key immune system component identified in these studies is not triggered, then vaccination fails” said Prof. Lichty.

Wan says this study could have further impact on a number of serious conditions and illnesse...

In the first experiment, two objects always appeared in the same position relative to the room’s boundary; the other two always appeared in the same spot relative to another object acting as a landmark. This image shows the boundary wall and a landmark object. Credit: University of Pennsylvania

Imagine a room or a landscape or a city street. Part of what differentiates that scene from a face or an object is the fact that it has boundaries, and Uni of Pennsylvania researchers Joshua Julian et al aimed to parse out which part of the brain helps perceive those borders. What they learned, through 2 experiments involving transcranial magnetic stimulation, TMS, is that this function falls to the occipital place area, OPA.

The OPA, located near the top of the back of the head, is known for its st...

Time-averaged local volume fraction ϕ(r) of interacting and noninteracting particles in a system with spatially patterned one-particle swim speed v(r), where v = vi = v0(1 – i/16) in the ith well and v = v0 between the wells. The solid lines show our predictions with a prefactor determined by least-squares fits, where we neglected the three highest density (ϕ > 0.5) data points for the interacting particles. Inset: Spatially resolved plot of ϕ(r) for the interacting particles; note the logarithmic scale on the color bar.

Light of a certain wavelength can be used to put so-called active materials into motion and control their movement...