Category Health/Medical

Researchers highlight Brain Region as ‘Ground 0’ of Alzheimer’s disease

brain stem (2nd version)

Blue indicates the location of the tiny locus coeruleus within the brainstem. (Photo/Shutterstock.com)

The locus coeruleus region of the brain is essential for maintaining cognitive function as a person ages, but is vulnerable to toxins and infection. The locus coeruleus is a small, bluish part of the brainstem that releases norepinephrine, the neurotransmitter responsible for regulating heart rate, attention, memory, and cognition. Its cells, or neurons, send branch-like axons throughout much of the brain and help regulate blood vessel activity. Its high interconnectedness may make it more susceptible to the effects of toxins and infections compared to other brain regions.

Prof...

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Microchip used to Build a 1st-ever Artificial Kidney

An example of the microchip filter being used inside Fissell's artificial kidney. Credit: Vanderbilt University

An example of the microchip filter being used inside Fissell’s artificial kidney. Credit: Vanderbilt University

Nephrologists are making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart. “We are creating a bio-hybrid device that can mimic a kidney to remove enough waste products, salt and water to keep a patient off dialysis,” said Fissell. Fissell says the goal is to make it small enough, roughly the size of a soda can, to be implanted inside a patient’s body.

“It’s called silicon nanotechnology. It uses the same processes that were developed by the microelectronics industry for computers,” said Fissell...

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Sweet Discovery in Leafy Greens holds Key to Gut Health

sulfoquinovose (SQ)

sulfoquinovose (SQ)

A critical discovery about how bacteria feed on an unusual sugar molecule found in leafy green vegetables could hold the key to explaining how ‘good’ bacteria protect our gut and promote health. Leafy greens are essential for feeding good gut bacteria, limiting the ability of bad bacteria to colonise the gut by shutting them out of the prime ‘real estate’.

Researchers identified a previously unknown enzyme used by bacteria, fungi and other organisms to feed on the unusual but abundant sugar sulfoquinovose (SQ) found in green vegetables. Each year, leafy green vegetables eg, spinach – produce the sugar on an enormous scale globally. The discovery could be exploited to cultivate the growth of ‘good’ gut bacteria...

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Researchers identify ‘Neurostatin’ that may Reduce the Risk of Alzheimer’s disease

Schematic illustration of the drug discovery strategy described in this work. The strategy consists of four steps: (1) A fragment-based approach that allows the identification of small molecules that interact with the aggregation-prone system, here Aβ42, including FDA-approved molecules for drug repurposing. (2) An in vitro kinetic analysis that identifies the specific molecular steps in the Aβ42 aggregation mechanism responsible for the generation of toxic species. (3) A further kinetic analysis to determine the mechanism of inhibition associated with the molecules identified in step 1. (4) An evaluation of the effects of these molecules on the formation of toxic species in vivo. In particular, the inhibition of primary nucleation is predicted to delay the aggregation without affecting the total number of oligomers generated by the aggregation process, whereas inhibiting elongation or secondary nucleation is predicted either to increase or to decrease the number of toxic oligomers, respectively (see text).

Schematic illustration of the drug discovery strategy described in this work. The strategy consists of four steps: (1) A fragment-based approach that allows the identification of small molecules that interact with the aggregation-prone system, here Aβ42, including FDA-approved molecules for drug repurposing. (2) An in vitro kinetic analysis that identifies the specific molecular steps in the Aβ42 aggregation mechanism responsible for the generation of toxic species. (3) A further kinetic analysis to determine the mechanism of inhibition associated with the molecules identified in step 1. (4) An evaluation of the effects of these molecules on the formation of toxic species in vivo...

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