Category Health/Medical

Clearance of senescent cells prolongs healthspan

Researchers have shown senescent cells – cells that no longer divide and accumulate with age – negatively impact health and shorten lifespan by as much as 35% in normal mice. The results demonstrate that clearance of senescent cells delays tumor formation, preserves tissue and organ function, and extends lifespan without observed adverse effects.

“Cellular senescence is a biological mechanism that functions as an ’emergency brake’ used by damaged cells to stop dividing,” says Jan van Deursen, Ph.D., Chair of Biochemistry and Molecular biology at Mayo Clinic...

Photo by Alexander Wild

A product called the OFF!® Clip-On™ repellent device could be an effective tool for preventing bites from the Aedes aegypti mosquito – the primary vector of Zika, chikungunya, dengue, and yellow fever. The OFF! Clip-On repels mosquitoes by releasing a vapor form of insecticide through a battery-powered fan, forming an insecticide “cloud” around the wearer of the device. In order to test the effectiveness of the device, Christopher Bibbs and Rui-De Xue of the Anastasia Mosquito Control District in Florida studied how the device performed against hungry Aedes aegypti mosquitoes. The study was done outdoors in order to replicate real-world conditions.

They found that the OFF! Clip-On caused high mosquito mortality and knockdown rates up to 0...

Representative images of control (left) and Dvl mutants (right) embryonic brains at embryonic day 18.5 (E18.5, just before birth at E20) were stained with DAPI to highlight all of the nuclei (Blue), anti-Ctip2 (Green) for deep layer neurons and anti-Cux1 (Red) for more superficial layer neurons. Analysis of the results shows specific reduction of the deep layer (Ctip2+) neurons at E18.5. This reduction in deep layer neurons is preceded by a transient brain over growth at E14.5, associated with increased proliferation of neural progenitors and premature differentiation. Credit: Case Western Reserve University School of Medicine

Autism has been postulated to be caused by neuron overgrowth in the prenatal period, although the precise timing and cause of this overgrowth has been unknown...

Inhibition of transcriptional interference with siRNA. The top panel depicts how GNG12-AS1 modulates the expression of the active DIRAS3 allele through transcriptional interference. GNG12-AS1 may act as a rheostat for DIRAS3 transcription rate. The lower panel depicts how exogenous siRNA molecules in a complex with AGO2 can bind to both the TSS and GNG12-AS1 to inhibit Pol II, and block further transcription initiation and elongation of GNG12-AS1. As a result of transcriptional silencing of GNG12-AS1, transcriptional interference is reduced leading to increased transcription of DIRAS3.

Supposed non-coding DNA, found in between genes, plays a role in suppressing cancer, according to new research by Universities of Bath and Cambridge...