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    Category Health/Medical

    Scientists have Identified Oxygen Sensor PHD1 Potential Target for Rx of brain Infarction (Ischemic stroke)

    January 7, 2016, Categories  Health/Medical, Biology/Biotechnology

    Highlights • Genetic loss of PHD1 provides substantial protection against brain ischemic injury • PHD1 loss reprograms glucose metabolism without vascular changes • Increased oxPPP flux, at the expense of glycolysis, enhances redox balance in neurons • Intracerebroventricular delivery of anti-PHD1 oligos protects against stroke

    Highlights • Genetic loss of PHD1 provides substantial protection against brain ischemic injury • PHD1 loss reprograms glucose metabolism without vascular changes • Increased oxPPP flux, at the expense of glycolysis, enhances redox balance in neurons • Intracerebroventricular delivery of anti-PHD1 oligos protects against stroke

    Despite (minor) improvements in stroke treatment, stroke remains the 4th leading cause of death and the most common reason of severe disability. Research led by Prof. Peter Carmeliet and Dr. Annelies Quaegebeur (VIB/KU Leuven) indicates inhibition of PHD1 offers protection against stroke, via an unexpected mechanism, raising hope for future stroke treatment.

    Brain cells rely on oxygen and glucose to generate energy, necessary to function normally...

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    Insulin-Producing Pancreatic Cells created from Human Skin Cells

    January 6, 2016, Categories  Health/Medical, Biology/Biotechnology

    Functioning human pancreatic cells after they've been transplanted into a mouse are shown. Credit: Saiyong Zhu

    Functioning human pancreatic cells after they’ve been transplanted into a mouse are shown. Credit: Saiyong Zhu

    When transplanted into mice, the cells protected them from developing diabetes in a mouse model of the disease by producing insulin in response to changes in glucose levels. The new study also presents significant advancements in cellular reprogramming technology, which will allow scientists to efficiently scale up pancreatic cell production and manufacture trillions of the target cells in a step-wise, controlled manner. This accomplishment opens the door for disease modeling and drug screening and brings personalized cell therapy a step closer.

    “Our results demonstrate for the first time that human adult skin cells can be used to efficiently and rapidly generate functional pancr...

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    Using Nanoparticles to Combat Arteriosclerosis

    January 6, 2016, Categories  Health/Medical, Biology/Biotechnology

    On the left are fluorescence-labeled cells with nanoparticles: The cellular nuclei are shown in blue, the fluorescence labeling is shown in green and the nanoparticles in the cells are identified by arrows. The middle photo shows a blood vessel populated with these cells (green). On the right is a detailed image of a vascular wall with the eNOS protein identified (red). Credit: Dr. Sarah Rieck/Dr. Sarah Vosen/University of Bonn

    On the left are fluorescence-labeled cells with nanoparticles: The cellular nuclei are shown in blue, the fluorescence labeling is shown in green and the nanoparticles in the cells are identified by arrows. The middle photo shows a blood vessel populated with these cells (green). On the right is a detailed image of a vascular wall with the eNOS protein identified (red). Credit: Dr. Sarah Rieck/Dr. Sarah Vosen/University of Bonn

    A method for guiding replacement cells to diseased vascular segments using nanoparticles has been developed. Arteriosclerosis is common with fatal consequences. Deposits in the arteries lead to strokes and heart attacks. They demonstrated in mice that fresh cells actually exert their curative effect in these segments...

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    Novel RNA Delivery System may Treat Incurable Blood Cancers

    January 5, 2016, Categories  Health/Medical, Biology/Biotechnology

    Mantle Cell Lymphoma - 4.

    Mantle cell lymphoma in the bone marrow may appear similar to other lymphoproliferative disorders. Immunohistochemical staining for cyclin D1 is helpful in diagnosing this entity.

    With a median survival rate of 5-7 yrs, Mantle Cell Lymphoma (MCL) is considered the most aggressive known blood cancer – and available therapies are scarce. 3000 Americans are diagnosed with MCL every year. Tel Aviv University researchers offer tangible hope of curing the currently incurable blood cancer – and others like it. The revolutionary system was found to successfully halt the proliferation of a cancer-related protein in WBCs in both animal models and samples taken from MCL patients.

    “MCL has a genetic hallmark,” said Dr. Peer...

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