Category Health/Medical

Dietary Restriction or Good Genes: New study tries to unpick which has a Greater Impact on Lifespan

A white mouse on a running wheel.
Was it exercise or 40% calorie restriction that helped these mice live longer? Tetra Images/Alamy Stock Photo

As people who research aging like to quip, the best thing you can do to increase how long you live is to pick good parents. After all, it has long been recognized that longer-lived people tend to have longer-lived parents and grandparents, suggesting that genetics influence longevity.

Complicating the picture, however, is that we know that the sum of your lifestyle, specifically diet and exercise, also significantly influences your health into older age and how long you live. What contribution lifestyle versus genetics makes is an open question that a recent study in Nature has shed new light on.

Scientists have long known that reducing calorie intake can make animals li...

Read More

Stretchable Transistors used in Wearable Devices enable In-Sensor Edge Computing

A wearable in-sensor computing module based on stretchable organic electrochemical transistors
Credit: Liu et al

Organic electrochemical transistors (OECTs) are neuromorphic transistors made of carbon-based materials that combine both electronic and ionic charge carriers. These transistors could be particularly effective solutions for amplifying and switching electronic signals in devices designed to be placed on the human skin, such as smart watches, trackers that monitor physiological signals and other wearable technologies.

In contrast with conventional neuromorphic transistors, OECTs could operate reliably in wet or humid environments, which would be highly advantageous for both medical and wearable devices. Despite their potential, most existing OECTs are based on stiff materials, which can reduce the comfort of wearables and thus hinder their large-scale deployment.

Read More

Gut Instincts: Intestinal Nutrient Sensors

A human intestinal organoid, displaying typical ‘budding crypts’ and a central ‘villus-like’ domain. The main intestinal cell types are shown in green, blue, red and purple. Membranes are yellow and nuclei cyan. Credit: Ninouk Akkerman, Yannik Bollen and Jannika Finger, Institute of Human Biology

A multi-institutional group of researchers led by the Hubrecht Institute and Roche’s Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion. In response to incoming food, these hormones are secreted by rare hormone producing cells in the gut and play key roles in managing digestion and appetite. The team has developed new tools to identify potential ‘nutrient sensors’ on these hormone producing cells and study their function...

Read More

Neuroscientists Discover a Mechanism that can Reactivate Dormant Neural Stem Cells

Image of a single quiescent neural stem cell with its hallmark cellular protrusion extending from the cell body from Drosophila larval brains six hours after larval hatching, with the membrane in orange and nuclear marker in blue. Credit: Mahekta R Gujar

An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells.

The research, published in Nature Communications, offers exciting potential for advancing our understanding and treatment of common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.

Neural stem cells are the source of the brain’s primary functional cells...

Read More