Category Health/Medical

Inhaled or injected into tumors of several types of cancer, the shell of cowpea mosaic virus with infectious components removed, in blue, turned on the immune system in mice to wipe out tumors and protect against metastases. Credit: Nicole Steinmetz

Scientists the 100yo in-situ vaccination idea. The idea was to put something inside a tumor and disrupt the environment that suppresses the immune system, thus allowing the natural defense system to attack the malignancy. They used the hard coating of cowpea mosaic virus, with no detectible side effects, which are a common problem with traditional therapies and some immunotherapies.

“The cowpea virus-based nanoparticles act like a switch that turns on the immune system to recognize and fight against the tumor – as well as to remember it,” said ...

The British study, which is the first of its kind, found that out of 51 IBS patients tested 82% exhibited insufficient vitamin D levels. Researchers from the University of Sheffield discovered a significant association between a patient’s vitamin D levels and the severity of their IBS symptoms, particularly the extent to which IBS affects their quality of life.

Dr Bernard Corfe, from the University’s Molecular Gastroenterology Research Group, said: “IBS is a poorly understood condition which impacts severely on the quality of life of sufferers. There is no single known cause and likewise no single known cure.”

IBS is a chronic and debilitating functional disorder of the GIT which affects 10-15% of the western population...

A new study sheds light on the inherited components of 12 cancer types. The research confirmed the well-known heritability of breast and ovarian cancers and found a surprising inherited component to stomach cancer. In the graphic above, Lung 1 is lung squamous cell carcinoma, and Lung 2 is lung adenocarcinoma. Credit: Sara Dickherber

In a new analysis, researchers have shed light on these hereditary elements across 12 cancer types – showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes, BRCA1 and BRCA2...

Molecular model showing the novel proposed mechanism for the activation of SMURF2. The C-lobe (in yellow) of the SMURF2 protein interacts with an ubiquitin molecule (in green), which was transferred to SMURF2 by USP15. Credit: Image courtesy of National University of Singapore

In certain settings, the TGF-beta pathway can act as an oncogene, enhancing cancer progression in humans. The activation of this pathway can increase the growth of tumors by promoting cell invasion, activating cancer stem cells, and in some cases, promoting the spread of cancer. In recent years, a number of deubiquitinating enzymes have been shown to regulate the TGF-β pathway and may potentially be considered as a new class of drug targets...