Category Health/Medical

Diet Lacking Soluble Fiber promotes Weight Gain, mouse study suggests

 

A new study highlights the importance of the gut microbiome in maintaining intestinal and metabolic health and suggests that eating more foods high in soluble fiber may help prevent metabolic disease and obesity.

Eating too much high-fat, high-calorie food is considered the primary cause of obesity and obesity-related disease, including diabetes. While the excess calories consumed are a direct cause of the fat accumulation, scientists suspect that low-grade inflammation due to an altered gut microbiome may also be involved. A new study finds in mice that a diet missing soluble fiber promotes inflammation in the intestines and poor gut health, leading to weight gain. Moreover, incorporating soluble fiber back into the diet can restore gut health.

Georgia State University team examined...

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Single treatment with curli fibres ameliorates TNBS colitis. Colitis was induced in 6–8-week female Balb/c (n=6–7) mice by intrarectal instillation of 1% TNBS in 50% ethanol or 50% ethanol as a vehicle control. Day 1 post TNBS enema, mice were administered treatments as follows: 0.1 mg curli (oral), 0.4 mg curli (oral), 0.1 mg anti-TNFα (i.p.) or no treatment. (a) survival (n=6), (b) histopathological scores at day 6 post TNBS induction were plotted and (c) H&E images were taken. (d) Stool consistency scores were determined at day 3 post TNBS induction. It should be noted that larger areas of immune cell infiltration and lymphoid follicles in the submucosa was determined in the colonic tissue of mice treated with TNBS alone as compared with the groups that received curli treatment (*P<0.05; **P<0.01; ****P<0.0001). H&E, hematoxylin and eosin; i.p., intraperitoneal; TNBS, 2,4,6-trinitrobenzene sulphonic acid; TNF, tumour necrosis factor; Tx, treatment.

Single treatment with curli fibres ameliorates TNBS colitis. Colitis was induced in 6–8-week female Balb/c (n=6–7) mice by intrarectal instillation of 1% TNBS in 50% ethanol or 50% ethanol as a vehicle control. Day 1 post TNBS enema, mice were administered treatments as follows: 0.1 mg curli (oral), 0.4 mg curli (oral), 0.1 mg anti-TNFα (i.p.) or no treatment. (a) survival (n=6), (b) histopathological scores at day 6 post TNBS induction were plotted and (c) H&E images were taken. (d) Stool consistency scores were determined at day 3 post TNBS induction...

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Single-agent Phototherapy System offers Efficacy of Cancer Diagnosis, Surgery and Rx around the world

This new single-agent phototherapy system may form a valuable new approach to fighting cancer. Credit: Graphic courtesy of Oregon State University

This new single-agent phototherapy system may form a valuable new approach to fighting cancer. Credit: Graphic courtesy of Oregon State University

Oregon State University today announced an important advance in the field of cancer imaging and phototherapy. It uses a single chemical compound, silicon naphthalocyanine, that has both diagnostic and therapeutic value. It makes cancer cells glow when exposed to near-infrared light, so a surgeon can identify the cancer and remove it + the compound creates heat and reactive oxygen species within any remaining cancer cells, killing them.

In tests completed with laboratory animals, tumors were completely eradicated without side effects, and did not return...

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Brain Mechanism for Creating Durable Memories

This is a photograph of brain areas whose pattern of activation matched significantly while watching a video and remembering that same video. Credit: James Keidel

This is a photograph of brain areas whose pattern of activation matched significantly while watching a video and remembering that same video. Credit: James Keidel

Rehearsing information immediately after being given it may be all you need to make it a permanent memory, a new study suggests. Psychologists found that the same area of the brain activated when laying down a memory is also activated when rehearsing that memory. It has implications for any situation in which accurate recall of an event is critical, such as witnessing an accident or crime.

The study showed that the brain region known as the posterior cingulate – an area whose damage is often seen in those with Alzheimer’s – plays a crucial role in creating permanent memories...

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