Category Health/Medical

A researcher holding up the prosthetic heart valve, called VeloX, which can be implanted in patients through a small incision. ST PHOTO: SEAH KWANG PENG

A novel prosthetic heart valve has been developed, called VeloX, which can be implanted through a small incision for the treatment of a serious heart valve disorder,ie mitral regurgitation (mitral valve on the left side of the heart does not close properly). The device is beneficial for those of high surgical risk or are unsuitable for existing clinical interventions.

Mitral valve regurgitation can lead to congestive heart failure or it may worsen an existing heart failure. 12 million people suffer from mitral regurgitation worldwide, with nearly 250,000 new patients diagnosed annually...

Wu et al. combine gnotobiotic mice colonized with defined collections of sequenced human gut bacteria with a method for performing whole genome transposon (Tn) mutagenesis to simultaneously identify bacterial genes required for the survival/success of different community members under different dietary conditions. Their analysis yielded a prebiotic that was used to deliberately change the representation of a prominent community member. Their approach has general utility for defining the resource requirements (niches) of microbial citizens of complex communities and for developing new ways for manipulating the properties of these communities. Credit: Laura Kyro

An international team of researchers working at the Washington University School of Medicine in Missouri has identified several g...

The hippocampus is a region of the brain largely responsible for memory formation. Credit: Salk Institute

A combined team of researchers have found 3 types of repressive regulations in the hippocampus of mice that impact memory retention. To gain a better idea of how genes are involved in the memory making process, the researchers trained several mice to fear being put into a cage, by administering electric shocks. They then killed the mice after differing amounts of time had passed (five minutes, ten minutes , a half hour and at four hours) and performed RNA sequencing and ribosome profiling on the hippocampus. Doing so led to the identification of 104 genes that deviated from a control group, each with either translation or transcription differences.

In studying the data, the researchers...

Highlights •Timeless interacts with PARP-1 independent of poly(ADP-ribosyl)ation •Crystal structures of Timeless PAB in free form and in complex with PARP-1 •Specific recognition of PARP-1 by Timeless does not affect its enzymatic activity •PARP-1 is required for Timeless recruitment to DSB sites to promote HR repair

A new molecular mechanism for DNA repair involving an unexpected interaction between PARP-1 protein and sleep proteins in humans has been found. While it is a well-known fact that sleep is important to the body’s recovery and healing, knowledge of the molecular mechanisms that make this possible is incomplete...