Category Health/Medical

In an advance that helps clarify the role of a cluster of neurons in the brain, researchers have found that these neurons not only control hunger and appetite, but also regulate bone mass. “We have found that the level of your hunger could determine your bone structure,” said Prof Tamas L. Horvat

“The less hungry you are, the lower your bone density, and surprisingly, the effects of these neurons on bone mass are independent of the effect of the hormone leptin on these same cells.”

Horvath and his team focused on agouti-related peptide (AgRP) neurons in the hypothalamus, which control feeding and compulsive behaviors...

DNA-Based Nanodevices for Molecular Medicine

A new article discusses how DNA molecules can be assembled into tailored and complex nanostructures, and further, how these structures can find uses in therapeutics and bionanotechnological applications. The researchers outline the superior properties of DNA nanostructures. Moreover, these DNA nanostructures provide new applications in molecular medicine, such as novel approaches in tackling cancer. Tailored DNA structures could find targeted cells and release their molecular payload selectively into the cells.

The big boom in the field of structural DNA nanotechnology happened in 2006, when Paul Rothemund introduced a technique dubbed ‘DNA origami’...

Both the acquired immune system and innate immune system has a memory. And BCG vaccine against tuberculosis can stimulate this memory. After a BCG vaccination, the innate immune system responds better to a wide range of other infections. Mihai Netea and colleagues from Radboud university medical center discovered and described how that works. They think that the old vaccine could be useful for specific target groups, such as the elderly.

BCG, a vaccine against TB, was discovered in the 1920s and is one of the most used vaccines worldwide. In the Netherlands, the vaccine no longer falls within the national vaccination program...

To visualize the neural pathways, two markers (red and green) were applied to two regions of the orbitofrontal cortex. These compounds then migrated, accumulating in the thalamic neurons. Dense labeling with the two tracers is visible in the submedius thalamic nucleus (delimited by a dotted line). Credit: Images generated at the Bordeaux Imaging Centre and obtained by Fabien Alcaraz

When faced with a change to our environment, we have to make appropriate decisions, which usually involves the orbitofrontal cortex. Yet unexpectedly, scientists have discovered that a brain region located in the thalamus also plays a crucial role in using these evolved skills.

Using a labeling technique, the scientists evidenced a specific area, the thalamic submedius nucleus, which is closely linked to the or...