Category Health/Medical

>>could improve Med Imaging/ Cancer Rx’s + Increase Solar Cell efficency by 25 – 30%. Goal is to turn low-energy colors of light, such as red, into higher-energy colors, like blue/green. A traditional solar cell can only absorb light with energy above a certain threshold. Infrared light passes right through, its energy untapped. But if low-energy could be transformed into higher-energy light, a solar cell could absorb more.

UD’s College of Engineering’s A/Prof Matthew Doty said; “You can’t simply turn a red photon into a blue one, but you can combine the energy from two or more red photons to make one blue photon.” …”Photon upconversion” isn’t new but UD team’s approach is. They want to design a new kind of semiconductor nanostructure that will act like a ratchet...

CRISPR-Cas9 and targeted sgRNAs can revert large inversions in hemophilia A iPSCs •Endothelial cells derived from corrected iPSCs express correctly spliced Factor VIII •Transplantation of corrected iPSCs can rescue injury mortality in hemophiliac mice •Whole-genome and targeted deep sequencing did not detect off-target mutations Credit: Chul-Yong Park, Duk Hyoung Kim, Jeong Sang Son, Jin Jea Sung, Jaehun Lee, Sangsu Bae, Jong-Hoon Kim, Dong-Wook Kim, Jin-Soo Kim. Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9. Cell Stem Cell, 2015; DOI:

Hemophilia A occurs in about 1 in 5,000 male births and almost half of severe cases are caused by identified “chromosomal inversions” involving introns 1 and 22 of the F...

Kinesin-14 promotes DSB mobility.

It’s a discovery that could unlock secrets into how cancer operates. “Scientists knew that severely injured DNA was taken to specialized ‘hospitals’ in the cell to be repaired, but the big mystery was how it got there,” said Professor Karim Mekhail, He discovered this DNA ambulance, which is a kinesin-14 motor protein complex, by using yeast cells.

Mekhail’s team also found that the DNA hospital, ie nuclear pore complex, repairs damaged DNA inaccurately. This inaccurate fix is important because DNA contains the instructions for all our genetic information. While the repaired DNA can still replicate, it has irregular cell instructions – a scenario that could cause cancer.

Daniel Durocher, Senior Investigator at Mount Sinai’s Lunenfeld-Tanenbaum Research I...

Prof. Hyung Joon Cha and his colleagues at POSTECH have developed new tissue adhesive that is mussel-protein based via a photochemical reaction using blue visible light. Myriad medical #applications including sutureless wound closures of delicate organs or tissues beyond surgeons’ reach.

Inspired by nature’, a new light-activated adhesive hydrogel has been developed. The innovative surgical protein glue, called LAMBA, not only closes an open wound on a wet bleeding site within less than 60 seconds but also effectively facilitates the healing process without inflammation or a scar. It works on the same principles as mussels attaching to underwater surfaces and insects maintaining structural balance and flexibility...