Category Technology/Electronics

The LLMs that have increasingly taken over the tech world are not “cheap” in many ways. The most prominent LLMs, such as GPT-4, took some $100 million to build in the form of legal costs of accessing training data, computational power costs for what could be billions or trillions of parameters, the energy and water needed to fuel computation, and the many coders developing the training algorithms that must run cycle after cycle so the machine will “learn.”

But, if a researcher needs to do a specializ...

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissors” but is much smaller and thus easier to transport into cells.

Using protein engineering and AI algorithms, University of Zurich researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future. The work has been published in Nature Methods.

CRISPR-Cas systems, which consist of protein and RNA components, we...

The interlocking bricks, which can be repurposed many times over, can withstand similar pressures as their concrete counterparts. Engineers developed a new kind of reconfigurable masonry made from 3D-printed, recycled glass. The bricks could be reused many times over in building facades and internal walls.

What if construction materials could be put together and taken apart as easily as LEGO bricks? Such reconfigurable masonry would be disassembled at the end of a building’s lifetime and reassembled into a new structure, in a sustainable cycle that could supply generations of buildings using the same physical building blocks.

That’s the idea behind cir...

By controlling silk protein nanostructure for the first time, scientists pave the way for advanced microelectronic and computing applications. Ultra-thin layers of silk deposited on graphene in perfect alignment represent a key advance for the control needed in microelectronics and advanced neural network development.

After thousands of years as a highly valuable commodity, silk continues to surprise. Now it may help usher in a whole new direction for microelectronics and computing.

While silk protein has been deployed in designer electronics, its use is currently limited in part because silk fibers are a messy tangle of spaghetti-like strands.

Now, a research team led by scientists at the Department of Energy’s Pacific Northwest National Laboratory has tamed the tangle...