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A new Gene Therapy Strategy, courtesy of Nature

3D illustration of cells releasing exosomes
3D illustration of cells releasing exosomes

Scientists have developed a new gene-therapy technique by transforming human cells into mass producers of tiny nano-sized particles full of genetic material that has the potential to reverse disease processes.

Though the research was intended as a proof of concept, the experimental therapy slowed tumor growth and prolonged survival in mice with gliomas, which constitute about 80 percent of malignant brain tumors in humans.

The technique takes advantage of exosomes, fluid-filled sacs that cells release as a way to communicate with other cells.

While exosomes are gaining ground as biologically friendly carriers of therapeutic materials – because there are a lot of them and they don’t prompt an immune response – the trick with gene therapy is f...

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Robots made from Self-Folding Kirigami Materials

series of photos showing simple, self-folding robots
Programmable active kirigami metasheets with more freedom of actuationProceedings of the National Academy of Sciences, 2019; 201906435 DOI: 10.1073/pnas.1906435116

Researchers have demonstrated how kirigami-inspired techniques allow them to design thin sheets of material that automatically reconfigure into new two-dimensional (2D) shapes and three-dimensional (3D) structures in response to environmental stimuli. The researchers created a variety of robotic devices as a proof of concept for the approach.

“This is the first case that we know of in which 2D kirigami patterns autonomously reshape themselves into distinct 3D structures without mechanical input,” says Jie Yin, an assistant professor of mechanical and aerospace engineering at North Carolina State University and correspondi...

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Exoplanets can be made Less Habitable by Stars’ Flares

3D render of unreal Trappist-1 exoplanets system
A researcher at NYUAD has discovered that exoplanets lacking sufficient shielding can be impacted by high radiation bursts from the star, known as ‘flares’

Astronomers found that not all exoplanets in habitable zones will be able to maintain hospitable conditions for life. Exoplanets in close proximity to stars are subject to radiation bursts which can disrupt habitable conditions unless the exoplanet has significant atmospheric or magnetic shielding.

The discovery of terrestrial exoplanets, planets that orbit stars outside the solar system, has been one of the most significant developments in modern astronomy...

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Deadly ‘Superbugs’ Destroyed by Molecular Drills

An illustration shows how motorized nanomachines triggered by light drill into bacteria, making a path for antibiotics. Experiments showed the bacteria became susceptible again to the antibiotic meropenem, to which it had developed resistance. Illustration by Don Thushara Galbadage

Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again.

Researchers at Rice University, Texas A&M University, Biola University and Durham (U.K.) University showed that motorized molecules developed in the Rice lab of chemist James Tour are effective at killing antibiotic-resistant microbes within minutes.

“These superbugs could kill 10 million people a ye...

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