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DNA Nanorobots Target HER2-Positive Breast Cancer cells

An Intelligent DNA Nanorobot with in Vitro Enhanced Protein Lysosomal Degradation of HER2

About 20% of breast cancers make abnormally high levels of a protein called human epidermal growth factor receptor 2 (HER2). When displayed on the surface of cancer cells, this signaling protein helps them proliferate uncontrollably and is linked with a poor prognosis. Now, researchers have developed a DNA nanorobot that recognizes HER2 on breast cancer cells, targeting them for destruction.

Current therapies for HER2-positive breast cancer include monoclonal antibodies, such as trastuzumab, that bind to HER2 on cells and direct it to the lysosome – an organelle that degrades biomolecules. Lowering the levels of HER2 slows cancer cell proliferation and triggers cell death...

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The Mystery of the Galaxy with no Dark Matter

Scientists Solve the Mystery of Galaxy with No Dark Matter
The ultra-diffuse galaxy KKS2000]04 (NGC1052-DF2), towards the constellation of Cetus, considered previously a galaxy with no dark matter. Credit: Trujillo et al.

Researchers have clarified one of the mysteries of 2018 in the field of extragalactic astrophysics: the supposed existence of a galaxy without dark matter. Galaxies with no dark matter are impossible to understand in the framework of the current theory of galaxy formation, because the role of dark matter is fundamental in causing the collapse of the gas to form stars. In 2018, a study published in Nature magazine announced the discovery of a galaxy that lacked dark matter, which made a strong impact, and occupied the covers of popular scientific magazines.

Now, according to an article published in the Monthly Notices of ...

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High levels of Rare Gut Bacteria may be linked to Restless Legs Syndrome

Image result for Restless Leg Syndrome: Does It Start With A Gut Feeling?
Daniel J Blum, Emmanuel During, Fiona Barwick, Polina Davidenko, Jamie M Zeitzer. 0009 Restless Leg Syndrome: Does It Start With A Gut Feeling? Sleep, 2019; 42 (Supplement_1): A4 DOI: 10.1093/sleep/zsz067.008

Possible relationship between gut microbial health and sleep disorder. Small intestine bacterial overgrowth (SIBO) may be more prevalent among patients with restless legs syndrome (RLS), according to preliminary findings from a small, new study.

Results show that SIBO was found in all seven participants who have RLS. In contrast, the prevalence of SIBO in the general population is estimated to be no more than 15%.

“We’ve observed extremely high rates of small intestinal bacterial overgrowth in the RLS group,” said lead author Daniel Jin Blum, Ph.D., D.B.S.M...

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Exomoons may be Home to Extra-terrestrial Life

Exoplanet-alien-life
Alien life search: Planet Fomalhaut B as viewed by the Hubble Telescope (Image: Getty)

New research looks at the possibility of moons outside our solar system causing gaps in the rings of planet J1407b. Moons orbiting planets outside our solar system could offer another clue about the pool of worlds that may be home to extra-terrestrial life, according to an astrophysicist at the University of Lincoln.

Exoplanets are planets outside our solar system and up to this point nearly 4,000 have been discovered. Only a small proportion of these are likely to be able to sustain life, existing in what is known as the habitable zone. But some planets, especially large gas giants, may harbour moons which contain liquid water.

Dr Sutton said: “These moons can be internally heated by the gra...

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