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Research provides a possible new reason why human disease burden increases so sharply from the sixth decade of life onward as health-protective mechanisms disappear.

Claes Wahlestedt, M.D., Ph.D., professor of psychiatry and behavioral sciences and associate dean for therapeutic innovation at the University of Miami Miller School of Medicine, is senior author of a new study – Longevity Related Molecular Pathways Are Subject to Midlife ‘Switch’ in Humans – published today in Aging Cell.

Working with first author Jamie Timmons, Ph.D...

About 20% of breast cancers make abnormally high levels of a protein called human epidermal growth factor receptor 2 (HER2). When displayed on the surface of cancer cells, this signaling protein helps them proliferate uncontrollably and is linked with a poor prognosis. Now, researchers have developed a DNA nanorobot that recognizes HER2 on breast cancer cells, targeting them for destruction.

Current therapies for HER2-positive breast cancer include monoclonal antibodies, such as trastuzumab, that bind to HER2 on cells and direct it to the lysosome – an organelle that degrades biomolecules. Lowering the levels of HER2 slows cancer cell proliferation and triggers cell death...

Researchers have clarified one of the mysteries of 2018 in the field of extragalactic astrophysics: the supposed existence of a galaxy without dark matter. Galaxies with no dark matter are impossible to understand in the framework of the current theory of galaxy formation, because the role of dark matter is fundamental in causing the collapse of the gas to form stars. In 2018, a study published in Nature magazine announced the discovery of a galaxy that lacked dark matter, which made a strong impact, and occupied the covers of popular scientific magazines.

Now, according to an article published in the Monthly Notices of ...

Possible relationship between gut microbial health and sleep disorder. Small intestine bacterial overgrowth (SIBO) may be more prevalent among patients with restless legs syndrome (RLS), according to preliminary findings from a small, new study.

Results show that SIBO was found in all seven participants who have RLS. In contrast, the prevalence of SIBO in the general population is estimated to be no more than 15%.

“We’ve observed extremely high rates of small intestinal bacterial overgrowth in the RLS group,” said lead author Daniel Jin Blum, Ph.D., D.B.S.M...