Using Drosophila (the fruit fly) as a model organism, the research team had identified a single nucleotide mutation in the mitochondrial DNA sequence which encodes one of the core energy producing genes.
“This mutation made males sterile but remarkably the ill effects were observed only in males; females who harbour this mutation maintain their fertility. This very same mutation that causes male infertility results in them living longer than flies that don’t have this mutation. However, while remaining fertile, females that carry this mutation have shorter lives,” Ms Camus said.
Co-author Dr Ted Morrow, University of Sussex, said that this mutation is not the only one located within the mitochondria to affect longevity.
Human mitochondrial DNA.
Dr Damian Dowling suggested the study represents a breakthrough when tracking naturally occurring, single mutations located at key energy producing genes within the mtDNA.
“This means that by pinpointing these single mutations, not only can we observe impacts on mitochondrial function associated with these mutations, but also on key health considerations like fertility and life expectancy,” Dr Dowling said.
“The remarkable thing about these findings is that these mutations affect male fruit flies very differently from females. Certain mutations appear to be beneficial to one sex, but harmful to the other. This provides novel insights and ways of thinking into how the genes of the mitochondria might also shape aspects of human health.” http://medicalxpress.com/news/2015-10-mitochondrial-dna-mutations-affect-male.html
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