longevity tagged posts

Organ-on-a-chip technology replicates decades of human aging in just four days

An array of microfluidic chips with circuit-like patterns on a metal wafer, illuminated in blue, pink, and yellow light.
A prototype wafer shows various configurations that the Stahl lab tested before settling on their current design. UC Berkeley photo by Mathew Burciaga

Over one billion people worldwide are over 60, and the population is projected to more than double by 2050. But as more people live into their 60s, 70s, and 80s, health care systems across the globe may face new challenges as they attempt to manage associated increases in age-related disease.

Metabolic biologist Andreas Stahl and preeminent longevity researcher Irina Conboy argue that the graying of the global population underscores the need to understand aging as a biological process, and how it might be slowed or reversed...

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Study suggests one common amino acid may affect how long men live

Study suggests one common amino acid may affect how long men live

A large new study suggests that higher levels of a common amino acid called tyrosine may be linked to a shorter lifespan in men.

The research, published recently in the journal Aging, examined whether blood levels of two amino acids, phenylalanine and tyrosine, were connected to how long people live.

Amino acids are building blocks of protein. They are found in protein-rich foods such as milk, eggs and meat, and are also sold as dietary supplements.

Researchers from the University of Hong Kong and the University of Georgia analyzed health and genetic data from more than 270,000 people in the U.K. Biobank, a large long-term health study in the U.K.

At first, both amino acids appeared to be tied to a higher risk of death...

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Turning the gut microbiome into a longevity factory

New research finds that low doses of the antibiotic cephalordine induces the cps operon in bacteria, visualized in red. This operon is responsible for synthesizing colanic acids, resulting in attenuation of age-related metabolic changes. Credit: Meng Wang

A team of researchers has found a way to turn the bacteria living in the digestive tracts of animals into factories that can produce compounds that promote longevity in their hosts—showing a potential new drug development strategy.

Janelia Senior Group Leader Meng Wang and her team study longevity and were interested in seeing how they could transfer their research findings about longevity-promoting compounds into practical applications.

One idea they had was to induce the body’s gut microbiota—a collection of bacteria in th...

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Mice Eating Less of Specific Amino Acid – overrepresented in diet of obese people – Live Longer, Healthier

Study: Mice that ate less of an obesity-associated amino acid lived longer, healthier
Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.10.005

A new study in mice, published recently in the journal Cell Metabolism, shows that cutting down the amount of a single amino acid called isoleucine can, among other benefits, extend their lifespan, make them leaner and less frail as they age and reduce cancer and prostate problems, all while the mice ate more calories.

There’s a popular saying in some circles that “a calorie is a calorie,” but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.

“We like to say a calorie is not just a calorie,” says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health...

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