Macronutrient content and characteristics of the dietary interventions
The 5-minute test measures biological markers in urine created by the breakdown of foods such as red meat, chicken, fish and fruit and vegetables. The analysis, developed by researchers from Imperial College London, Newcastle University and Aberystwyth University, also gives an indication of how much fat, sugar, fibre and protein a person has eaten. Although the work is at an early stage, the team hope that with future development the test will be able to track patients’ diets. It could even be used in weight loss programs to monitor food intake.
Evidence suggests people inaccurately record their own diets, and under-report unhealthy food while over-reporting fruit and vegetable intake – and that the likelihood of inaccuracies in food diaries increases if a person is overweight or obese. Professor Gary Frost said: “A major weakness in all nutrition and diet studies is that we have no true measure of what people eat. We rely solely on people keeping logs of their daily diets — but studies suggest around 60% of people misreport what they eat to some extent. This test could be the first independent indicator of the quality of a person’s diet – and what they are really eating.”
Method: The researchers asked 19 volunteers to follow 4 different diets, ranging from very healthy to veryunhealthy. These were formulated using World Health Organisation dietary guidelines, which advise on the best diets to prevent conditions such as obesity, diabetes and heart disease. The volunteers strictly followed these diets for 3 days while in a London research facility, throughout which the scientists collected urine samples in the morning, afternoon and evening. The team assessed the urine for hundreds of metabolites. These included compounds that indicate red meat, chicken, fish, fruit and vegetables, as well as giving a picture of the amount of protein, fat, fibre and sugar eaten. They also included compounds that point to specific foods such as citrus fruits, grapes and green leafy vegetables.
The MCCV–PLS-DA model of metabolic patterns of the four diets for 19 participants
Results: From this information the researchers were able to develop a urine metabolite profile that indicated a healthy, balanced diet with a good intake of fruit and vegetables. The idea is this ‘healthy diet’ profile could be compared to the diet profile from an individual’s urine, to provide an instant indicator of whether they are eating healthily. The scientists then tested the accuracy of the test on data from a previous study. This included 225 UK volunteers as well as 66 people from Denmark. All of the volunteers had provided urine samples, and kept information on their daily diets. Analysis of these urine samples enabled the researchers in the current study to accurately predict the diet of the 291 volunteers.
Dr Isabel Garcia-Perez, co-author from the Faculty of Medicine at Imperial explained: “We need to develop the test further so we can monitor the diet based on a single urine sample, as well as increase the sensitivity. This will eventually provide a tool for personalised dietary monitoring to help maintain a healthy lifestyle. We’re not at the stage yet where the test can tell us a person ate 15 chips yesterday and two sausages, but it’s on the way.” The technology may one day be used alongside weight loss programmes, as well as patient rehabilitation, for instance to help heart attack patients follow a healthy diet.
Professor Elaine Holmes, co-author from the Department of Surgery and Cancer at Imperial added: “We are hoping to make this test available to the public within the next 2 years. The idea would be to collect a urine sample at home and deliver it to a local centre for analysis. We envisage the tool being used by dieticians to help guide their patients’ dietary needs, or even by individuals who are interested in finding out more about the relationship between diet and their health”
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