Difficult-to-treat, chronic wounds in preclinical models healed with normal scar-free skin after treatment with an acellular product discovered at Mayo Clinic. Derived from platelets, the purified exosomal product, known as PEP, was used to deliver healing messages into cells of preclinical animal models of ischemic wounds. The Mayo Clinic research team documented restoration of skin integrity, hair follicles, sweat glands, skin oils and normal hydration.

Ischemic wounds occur when arteries are clogged or blocked, preventing important nutrients and oxygen from reaching the skin to drive repair. This groundbreaking study titled, “TGF-β Donor Exosome Accelerates Ischemic Wound Healing,” is published in Theranostics.

“This paper documents that PEP, an off-the-shelf, room-temperatu...

The ability to turn on and off a physical process with just one photon is a fundamental building block for quantum photonic technologies. Realizing this in a chip-scale architecture is important for scalability, which amplifies a breakthrough by City College of New York researchers led by physicist Vinod Menon. They’ve demonstrated for the first time the use of “Rydberg states” in solid state materials (previously shown in cold atom gases) to enhance nonlinear optical interactions to unprecedented levels in solid state systems. This feat is a first step towards realizing chip-scale scalable single photon switches.

In solid state systems, exciton-polaritons, half-light half-matter quasiparticles, which result from the hybridization of electronic excitations (excitons) and photons, a...

A new study simulated 25,000 scenarios of black holes and neutron stars colliding, aiming to see how many would likely be detected by instruments on Earth in the mid- to late-2020s. The researchers found that, by 2030, instruments on Earth could sense ripples in space-time caused by up to 3,000 such collisions, and that for around 100 of these events, telescopes would also see accompanying explosions of light.

Studying the violent collisions of black holes and neutron stars may soon provide a new measurement of the Universe’s expansion rate, helping to resolve a long-standing dispute, suggests a new simulation study led by researchers at UCL (University College London).

Our two current best ways of estimating the Universe’s rate of expansion – measuring the brightness and speed ...

Goethe University researchers investigate oxidative stress in mice. Originally, oxygen radicals — reactive oxygen species, or ROS for short — were considered to be exclusively harmful in the body. They are produced, for example, by smoking or UV radiation. Because of their high reactivity, they can damage many important molecules in cells, including the hereditary molecule DNA. As a result, there is a risk of inflammatory reactions and the degeneration of affected cells into cancer cells.

Because of their damaging effect, however, ROS are also deliberately produced by the body, for example by immune or lung epithelial cells, which destroy invading ...