How Allergens Trigger Itching: Finding points to new targets for allergy drug development

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Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to AllergensImmunity, 2020; DOI: 10.1016/j.immuni.2020.10.001

A key step in the immune system’s response to allergens has been uncovered by researchers at Massachusetts General Hospital (MGH). They have shown that a neuropeptide called Substance P is released by certain neurons in the skin when they detect allergens, and that this substance is essential in the development of allergen-induced immune responses. This research could lead to the development of new and better methods to treat and prevent allergies.

How allergens are detected by the immune system had not been known...

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Smart Tablecloth can Find Fruit and Help with Watering the Plants Interactive fabric senses everyday non-metallic objects

Avocado, grapefruit on a smart tablecloth
The Capacitivo smart fabric can identify fruit and find lost objects. Overall, the system achieved a 94.5% accuracy in testing. Figure courtesy of XDiscovery Lab.

Researchers have designed a smart fabric that can detect non-metallic objects ranging from avocadoes to credit cards, according to a study from Dartmouth College and Microsoft Research. The fabric, named Capacitivo, senses shifts in electrical charge to identify items of varying shapes and sizes.

A study and demonstration video describing the sensing system were presented at the ACM Symposium on User Interface Software and Technology (UIST 2020).

“This research has the potential to change the way people interact with computing through everyday soft objects made of fabrics,” said Xing-Dong Yang, an assistant professor of...

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Where were Jupiter and Saturn Born?

Jupiter image courtesy of NASA.

An additional planet between Saturn and Uranus was kicked out of the Solar System in its infancy. New work led by Carnegie’s Matt Clement reveals the likely original locations of Saturn and Jupiter. These findings refine our understanding of the forces that determined our Solar System’s unusual architecture, including the ejection of an additional planet between Saturn and Uranus, ensuring that only small, rocky planets, like Earth, formed inward of Jupiter.

In its youth, our Sun was surrounded by a rotating disk of gas and dust from which the planets were born...

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Water on Ancient Mars

A dark rock
Black Beauty. Martian meteorite NWA 7533 is worth more than its weight in gold. © NASA/Luc Labenne

Analysis of a Martian meteorite reveals evidence of water 4.4 billion years ago. Certain minerals from the Martian crust in the meteorite are oxidized, suggesting the presence of water during the impact that created the meteorite. The finding helps to fill some gaps in knowledge about the role of water in planet formation.

Several years ago, a pair of dark meteorites were discovered in the Sahara Desert. They were dubbed NWA 7034 and NWA 7533, where NWA stands for North West Africa and the number is the order in which meteorites are officially approved by the Meteoritical Society, an international planetary science organization...

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