One-time Treatment Generates New Neurons, Eliminates Parkinson’s disease in mice

Left: mouse astrocytes (green) before reprogramming; Right: neurons (red) induced from mouse astrocytes after reprogramming with PTB antisense oligonucleotide treatment.

Researchers have discovered that a single treatment to inhibit a gene called PTB in mice converts native astrocytes, brain support cells, into neurons that produce the neurotransmitter dopamine. As a result, the mice’s Parkinson’s disease symptoms disappear.

Xiang-Dong Fu, PhD, has never been more excited about something in his entire career. He has long studied the basic biology of RNA, a genetic cousin of DNA, and the proteins that bind it. But a single discovery has launched Fu into a completely new field: neuroscience.

For decades, Fu and his team at University of California San Diego School of Medicine studied a pr...

Read More

Amorphous Boron Nitride shows excellent Insulating Properties for Next Generation of Electronics

a) Remote ICP-CVD system with borazine mass flow controller (MFC) for precise control of borazine flow. The a-BN films were grown on Si substrates at 400 °C. Credit: UNIST, SAIT, University of Cambridge, Catalan Institute of Nanoscience and Nanotechnology
b) Side view of images of a -BN sample grown on a Si substrate at T= 673K. Atomic species are shown in different colours: Si (yellow), Blue (N), Pink 3 (B). Credit: UNIST, SAIT, University of Cambridge, Catalan Institute of Nanoscience and Nanotechnology

In the ongoing process of miniaturization of logic and memory devices in electronic circuits, reducing the dimensions of interconnects—metal wires that link different components on a chip—is crucial to guarantee fast response of the device and improve its performance...

Read More

Hubble watches the ‘Flapping’ of Cosmic Bat Shadow in the Serpens Nebula

The young star HBC 672 is known by its nickname of Bat Shadow because of its wing-like shadow feature. The NASA/ESA Hubble Space Telescope has now observed a curious “flapping” motion in the shadow of the star’s disc for the first time. The star resides in a stellar nursery called the Serpens Nebula, about 1300 light-years away.

The young star HBC 672 is known by its nickname of Bat Shadow because of its wing-like shadow feature. The NASA/ESA Hubble Space Telescope has now observed a curious “flapping” motion in the shadow of the star’s disc for the first time. The star resides in a stellar nursery called the Serpens Nebula, about 1300 light-years away.

The Hubble Space Telescope captured a striking observation of the fledgling star’s unseen, planet-forming disc in 2018...

Read More

Protein in Mitochondria appears to Regulate Halth and Longevity

Having greater amounts of the peptide humanin is closely correlated with longer lives and better health in both animals and humans, including lower risk for Alzheimer’s.

A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.

The researchers examined humanin, a peptide encoded in the small genome of mitochondria — the powerhouses of the cell. From experiments in laboratory animals to measurements in human patients, the multi-site collaboration demonstrates how higher levels of humanin in the body are connected to longer lifespans and better health. It is linked to a lower risk for diseases such as Alzheimer’s.

“Humanin has long been known to...

Read More