Surplus Antioxidants are Pathogenic for Hearts and Skeletal Muscle

3d rendered illustration of a jogger's muscles.
This discovery may have clinical importance in management of heart failure.

This discovery may have clinical importance in management of heart failure. Oxidative stress can be pathological. Now researchers report that the other end of the redox spectrum, reductive stress, is also pathological. Reductive stress causes pathological heart enlargement and diastolic dysfunction in a mouse model.

Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress — where the redox teeter-totter has gone too far up — through production of endogenous antioxidants that reduce the reactive oxygen species. This balancing act is called redox homeostasis.

But what happens if the redox teeter-totter goes too far down, crea...

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Speeding up Long-Range Coherent LiDAR

Johann Riemensberger, Anton Lukashchuk, Maxim Karpov, Wenle Weng, Erwan Lucas, Junqiu Liu, Tobias J. Kippenberg. Massively parallel coherent laser ranging using soliton microcombs, Nature 13 May 2020. DOI: 10.1038/s41586-020-2239-3

LiDAR is a technique used for measuring distances with laser light. Researchers now show a new way to speedup a type of LiDAR engine by using photonic circuits. Light detection and ranging (LiDAR) comprised an array of techniques using laser light to measure distances by multiplying the time delay between transmitted and received optical signals with the speed of light. Modern 3D LiDAR sensors combine high lateral/vertical and radial resolution, and are key components in the ongoing revolution of level 4 and 5 self-driving cars.

The prominence of 3D LiDAR...

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What’s Mars made of?

(left) line graphs on a white background and (right) grey textured rectangles on a black background
Sound velocity measurements. Pulsed waves propagate through samples at the speed of sound. © 2020 Nishida et al.

Researchers simulate the core of Mars to investigate composition and origin. Earth-based experiments on iron-sulfur alloys thought to comprise the core of Mars reveal details about the planet’s seismic properties for the first time. This information will be compared to observations made by Martian space probes in the near future. Whether the results between experiment and observation coincide or not will either confirm existing theories about Mars’ composition or call into question the story of its origin.

Mars is one of our closest terrestrial neighbors, yet it’s still very far away – between about 55 million and 400 million kilometers depending on where Earth and Mars ...

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Excess Coffee Consumption a Culprit for Poor Health

sick face on froth of coffee
Association between habitual coffee consumption and multiple disease outcomes: A Mendelian randomisation phenome-wide association study in the UK Biobank
Konstance Nicolopoulos, Anwar Mulugeta, Ang Zhou,Elina Hyppönen

Published:March 13, 2020DOI:https://doi.org/10.1016/j.clnu.2020.03.009

Cappuccino, latte or short black, coffee is one of the most commonly consumed drinks in the world. But whether it’s good or bad for your health can be clarified by genetics, as a world-first study from the University of South Australia’s Australian Centre for Precision Health shows that excess coffee consumption can cause poor health.

Using data from over 300,000 participants in the UK Biobank, researchers examined connections between genetically instrumented habitual coffee consumption and a full ra...

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