Pedal to the metal: Speeding up Treatments for ALS

TDP-43 is the red protein being expressed in yeast. Some of it is being sent to inside an organelle called the vacuole in yeast (lysosome in humans), which is the blue circle. Buchan describes the lysosome as the trash compactor/recycling depot of the cell that endocytosis and autophagy send their substrates too. (Courtesy: Ross Buchan)
TDP-43 is the red protein being expressed in yeast. Some of it is being sent to inside an organelle called the vacuole in yeast (lysosome in humans), which is the blue circle. Buchan describes the lysosome as the trash compactor/recycling depot of the cell that endocytosis and autophagy send their substrates too. (Courtesy: Ross Buchan)

A therapeutic intervention for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig’s disease, could be on the horizon thanks to unexpected findings by University of Arizona researchers.

ALS is the progressive degeneration of motor neurons that causes people to lose the ability to move and eventually speak, eat and breathe.

Within the neuronal cells of patients with ALS and other neurodegenerative diseases, two proteins – TDP-43 and FUS – a...

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New technology could help solve AI’s ‘Memory Bottleneck’

An optical image of the device structure with 4 micrometer pillar diameter. Credit: Northwestern University/University of Messina, Italy
An optical image of the device structure with 4 micrometer pillar diameter. Credit: Northwestern University/University of Messina, Italy

Magnetic memory device is smallest demonstrated and uses record-low current. Memory-hungry, power-sapping big data might finally have met its match.

Electrical engineers at Northwestern University and the University of Messina in Italy have developed a new magnetic memory device that could potentially support the surge of data-centric computing, which requires ever-increasing power, storage and speed.

Based on antiferromagnetic (AFM) materials, the device is the smallest of its kind ever demonstrated and operates with record-low electrical current to write data.

“The rise of big data has enabled the emergence of artificial intelligence (AI)...

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Study reveals details of ‘golf ball asteroid’

Two views of the asteroid Pallas, which researchers have determined to be the most heavily cratered object in the asteroid belt.
Image courtesy of the researchers

The asteroid is named Pallas, after the Greek goddess of wisdom, and was originally discovered in 1802. Pallas is the third largest object in the asteroid belt, and is about one-seventh the size of the moon. For centuries, astronomers have noticed that the asteroid orbits along a significantly tilted track compared with the majority of objects in the asteroid belt, though the reason for its incline remains a mystery.

In a paper published today in Nature Astronomy, researchers reveal detailed images of Pallas, including its heavily cratered surface, for the first time.

The researchers suspect that Pallas’ pummeled s...

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Human Textiles to Repair Blood Vessels

Made entirely from biological material, these blood vessels would have the advantage of being well tolerated by all patients.© Nicolas L’Heureux

What if we could replace a patient’s damaged blood vessels with brand new ones produced in a laboratory? This is the challenge set by Inserm researcher Nicolas L’Heureux, who is working on the human extracellular matrix – the structural support of human tissues that is found around practically all of the body’s cells.

In a study published in Acta Biomaterialia, L’Heureux and his colleagues at the Tissue Bioengineering unit (Inserm/Université de Bordeaux) describe how they have cultivated human cells in the laboratory to obtain extracellular matrix deposits high in collagen – a structural protein that constitutes the mechanical scaffold...

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