Fat-Dissolving Bile Acids may help regulate Gut Immunity and Inflammation

fat cells in stomach
The acids that break down fat in our intestines may also play a role in gut immunity and inflammation
Image: Ugreen/iStock / Getty Images Plus

Could bile acids—the fat-dissolving juices churned out by the liver and gallbladder—also play a role in immunity and inflammation? The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.

The findings of the two studies, both conducted in mice, show that bile acids promote the differentiation and activity of several types of T cells involved in regulating inflammation and linked to intestinal inflammatory conditions. They also reveal that gut microbes are critical for converting bile acids into immune-signaling molecules.

The work suggests possible therapeutic pathways for modulating ...

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Hey Google, do you really record everything I say? Yes

Credit: CC0 Public Domain

Google says it only records interactions with connected devices like the Google Home speaker when we use the “wake word,” of “Hey, Google,” or “OK, Google.” But when using many of the Google smartphone apps with a microphone for voice search, or even Google on the desktop with voice commands, it can actually record every word you say to it—whether you use the wake word or not.

The fine print is that you have to click on the microphone in the apps to communicate with Google. (For queries like “Hey, Google, find Italian restaurants near me.”) Once you do that, Google will start transcribing you, word for word, and storing your commands, in text and audio, as U.S. TODAY discovered in tests this week.

This is similar to Google’s monitoring of our keystro...

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New Radiotracer offers opportunities for Earlier Intervention after Heart Attack

 Binding specificity test. (A) PET/CT axial views, autoradiographs, and corresponding H&E stainings of 10-micron cross-sections prepared from MI nonblocked, blocked, and sham-operated rats. Autoradiographs and H&E stainings from nonblocked hearts show increased Ga-68-FAPI-04 uptake in infarcted area at 7 days after MI, whereas uptake is negligible after sham operation or injection of nonlabeled FAPI-04 (blocked). Infarcted areas in H&E stainings are identified with arrows. (B) PET image–derived infarct-to-noninfarct uptake ratio (derived from 6 nonblocked and 3 blocked rat hearts subjected to coronary ligation). (C) Autoradiography image–derived infarct-to-noninfarct uptake ratio (derived from 3 nonblocked and 3 blocked MI hearts). QL = quantum level.

New radiotracer offers opp...

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Supercharging tomorrow: Team develops world’s most efficient Lithium-Sulfur Battery

Associate Professor Matthew Hill, Dr. Mahdokht Shaibani and Professor Mainak Majumder. Credit: Monash University

Imagine having access to a battery, which has the potential to power your phone for five continuous days, or enable an electric vehicle to drive more than 1000km without needing to “refuel”.

Monash University researchers are on the brink of commercialising the world’s most efficient lithium-sulphur (Li-S) battery, which could outperform current market leaders by more than 4X, and power Australia and other global markets well into the future.

Dr...

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