Why Intense Light can Protect Cardiovascular Health

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Highlights
•Intense light-mediated cardioprotection requires endothelial-specific PER2
•Intense light-elicited PER2 transcriptionally reprograms the endothelium
•Endothelial PER2 regulates respiration and barrier function during hypoxia
•Studies of humans reveal intense light activates PER2-dependent metabolism

The light boosts a critical gene that strengthens blood vessels. Researchers at the University of Colorado Anschutz Medical Campus have found that intense light amplifies a specific gene that bolsters blood vessels and offers protection against heart attacks.

“We already knew that intense light can protect against heart attacks, but now we have found the mechanism behind it,” said the study’s senior author Tobias Eckle, MD, PhD, professor of anesthesiology at the University...

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Nanosecond Pulsed Electric fields activate Immune cells

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Analysis of extracellular DNA by agarose gel electrophoresis. (A) Schematic representation of MNase treatment for liberation of extruded DNA from cells. MNase digests extracellular chromosomal DNA at its linker regions among nucleosomes, leading to the liberation of extracellular chromosomal DNA from their originating cells. Liberated DNA was separated from cells by brief centrifugation and in turn subjected to either DNA purification followed by agarose gel electrophoresis (B) or direct fluorometric measurement with a SYTOX Green dye (Fig. 4). (B) Analysis of MNase-treated extracellular DNA by agarose gel electrophoresis. Differentiated (D) and undifferentiated cells (U) were exposed to the indicated shot numbers of 20 kV/cm nsPEFs...
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Direct Detection of Circulating Tumor cells in Blood Samples

Enhanced Glow: Direct detection of circulating tumor cells in blood samples
Enhanced Glow: Direct detection of circulating tumor cells in blood samples

Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity. In the journal Angewandte Chemie, scientists have now introduced an ultrasensitive method for the direct detection of circulating tumor cells in blood samples. It is based on the amplified, time-resolved fluorescence measurement of luminescent lanthanide ions released from nanoparticles that bind specifically to tumor cells.

Conventional techniques for the detection of circulating tumor cells require complicated enrichment before detection because a sample of 10 million blood cells only contains about one tumor cell...

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Outbursts of Hot Wind detected Close to Black Hole

Credit: John Paice/University of Southampton/Inter-University Centre for Astronomy

An international team of astrophysicists from Southampton, Oxford and South Africa have detected a very hot, dense outflowing wind close to a black hole at least 25,000 light-years from Earth.

Lead researcher Professor Phil Charles from the University of Southampton explained that the gas (ionised helium and hydrogen) was emitted in bursts which repeated every 8 minutes, the first time this behaviour has been seen around a black hole. The findings have been published in the journal Monthly Notices of the Royal Astronomical Society.

The object Professor Charles’ team studied was Swift J1357...

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