Delivering TB vaccine Intravenously dramatically Improves Potency, study shows

3D PET CT scans of monkey lungs showing inflammation (red and yellow) from TB infection. The top row were vaccinated the usual way with a shot into the skin The bottom row received the vaccine intravenously.
CREDIT
JoAnne Flynn, Ph.D., Alexander White, Pauline Maiello, and Mario Roederer, Ph.D.

Worldwide, more people die from tuberculosis (TB) than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn’t that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power.

Researchers at the University of Pittsburgh School of Medicine and the National Institute of Allergy and Infectious Diseases (NIAID) discovered that intravenous TB vaccination is highly protecti...

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Objective Subtle Cognitive Difficulties predict Amyloid Accumulation and Neurodegeneration

A rendering of amyloid protein plaques accumulating between neurons in the brain
A rendering of amyloid protein plaques accumulating between neurons in the brain. Credit: National Institute of Aging

Rresearchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report that accumulating amyloid – an abnormal protein linked to neurodegenerative conditions such as Alzheimer’s disease (AD) – occurred faster among persons deemed to have “objectively-defined subtle cognitive difficulties” (Obj-SCD) than among persons considered to be “cognitively normal.”

Classification of Obj-SCD, which has been previously shown to predict progression to mild cognitive impairment (MCI) and dementia, is determined using non-invasive but sensitive neuropsychological measures, including measures of how efficiently someone learns ...

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In leap for Quantum Computing, Silicon quantum Bits establish a Long-distance Relationship

silicon-spin quantum bit
The team showed that a silicon-spin quantum bit (shown in the box) can communicate with another quantum bit located a significant distance away on a computer chip. The feat could enable connections between multiple quantum bits to perform complex calculations.
Image by Felix Borjans

In an important step forward in the quest to build a quantum computer using silicon-based hardware, researchers have succeeded in making possible the exchange of information between two qubits located relatively far apart – about the length of a grain of rice, which is a considerable distance on a computer chip. Connecting two silicon qubits across this distance makes possible new and more complex silicon-based quantum computer circuits.

Imagine a world where people could only talk to their next-door ne...

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Blazar Variability

An artist’s conception of a blazar, a galay powered by an active nucleus. Blazars are the most common sources detected by NASA’s Fermi gamma-ray spacecraft. Astronomers have modeled the bright, variable emission from the blazar CTA102 between 2013-2017 using data taken from the gamma-ray to radio bands. They are able to explain the multiuwavelegnth variability observed using a geometrical model for the rapidly moving jets. Credit: M. Weiss/CfA

Active galactic nuclei (AGN) are supermassive black holes at the centers of galaxies that are accreting material. These AGN emit jets of charged particles that move at speeds close to that of light, transporting huge amounts of energy away from the central black hole region and radiating across the electromagnetic spectrum...

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