Researchers Wirelessly Hack ‘Boss’ Gene, a step toward Reprogramming the human Genome

Two microscope images showing the FGFR1 in its normal state and when it's activated by laser light.
The left image above shows the gene FGFR1 in its natural state. The right image shows the gene when exposed to laser light, which causes the gene to activiate and deactivate. Credit: University at Buffalo.

Advance, made possible by tiny photonic implants, could lead to new treatments for cancer, mental disorders. A new University at Buffalo-led study describes how researchers wirelessly controlled FGFR1 – a gene that plays a key role in how humans grow from embryos to adults – in lab-grown brain tissue.

The ability to manipulate the gene, the study’s authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia. The work – spearheaded by UB researchers Josep M. Jornet, Michal K. Stachowiak, Yongho Bae and Ewa K...

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Powering the Future with Lunar Soil

Moon base. Credit: European Space Agency

Building a lunar base would be one of the next logical steps in our exploration of the solar system, but the survival of a future crew depends on access to a reliable source of energy. An ESA Discovery & Preparation study explored how lunar regolith—the dust, soil and rock on the moon’s surface—could be used to store heat and provide electricity for future astronauts, rovers and landers.

Humans would have little difficulty reaching the moon’s surface with today’s technology, but it is expensive—sometimes even impossible—to take all the materials we would need with us, especially if we want to stay for more than a couple of days...

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New research identifies gene that Hides Cancer cells from Immunotherapy

Highlights

•The early embryonic transcription factor DUX4 is active in many human cancers
•DUX4-expressing cancers are characterized by low anti-tumor immune activity
•DUX4 blocks interferon-γ-mediated induction of MHC class I and antigen presentation
•DUX4 is significantly associated with failure to respond to anti-CTLA-4 therapy

A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published today in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, it can prevent the cancer from being recognized and destroyed by the immune system.

The team, led by Drs...

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200 Times Faster than ever before: The Speediest Quantum Operation yet

 Two-qubit SWAP gate with truth table.

A group of scientists led by 2018 Australian of the Year Professor Michelle Simmons has achieved the first two-qubit gate between atom qubits in silicon – a major milestone on the team’s quest to build an atom-scale quantum computer. The pivotal piece of research was published today in the journal Nature.

A two-qubit gate is the central building block of any quantum computer – and the UNSW team’s version of it is the fastest that’s ever been demonstrated in silicon, completing an operation in 0.8 nanoseconds, which is ~200 times faster than other existing spin-based two-qubit gates.

In the Simmons’ group approach, a two-qubit gate is an operation between two electron spins – comparable to the role that classical logic gates play in con...

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