NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors

NAD⁺ restores memory in Alzheimer's' disease models by correcting RNA errors
NR induces transcription of genes involved in axon development, oxygen metabolism, mitochondrion localization, and autophagy in tauopathy mice. GO terms enriched in each of the eight classes of clusters in (A); each circular bar graph represents one cluster or class of clusters, and bar length correlates with the number of DEGs represented. GO terms shown in red font relate to mRNA. Clusters 4 and 5 are similar and are grouped together. Class 1 includes clusters 1, 2, and 6 marked with red. Class 2 includes clusters 4 and 5 marked with orange. Class 3 includes cluster 8 marked with yellow. GTPase, guanosine triphosphatase; NAD(P)H, reduced form of NAD phosphate; IRES, internal ribosomal entry site; GTP, guanosine 5′-triphosphate; MHC, major histocompatibility complex. Credit: Science A...
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First full simulation of 50 qubit universal quantum computer achieved

New record on JUPITER: Simulating a 50-qubit quantum computer
View between the racks of JUPITER. Credit: Forschungszentrum Jülich / Sascha Kreklau

A research team at the Jülich Supercomputing Center, together with experts from NVIDIA, has set a new record in quantum simulation: for the first time, a universal quantum computer with 50 qubits has been fully simulated—a feat achieved on Europe’s first exascale supercomputer, JUPITER, inaugurated at Forschungszentrum Jülich in September.

The result surpasses the previous world record of 48 qubits, established by Jülich researchers in 2022 on Japan’s K computer. It showcases the immense computational power of JUPITER and opens new horizons for developing and testing quantum algorithms. The research is published on the arXiv preprint server.

Quantum computer simulations are vital for develo...

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How to spot life in the clouds on other worlds

Cloud cover is bad for picnics and for viewing stars through a telescope. But an exoplanet with dense or even total cloud cover could help astronomers search for signs of life beyond our planet.

Cornell researchers have created the first reflectance spectra—a color-coded key—of diverse, colorful microorganisms that live in the clouds floating above Earth’s surface. Astronomers don’t know if these bacteria exist elsewhere in the universe and in enough abundance to be detected by telescopes; on Earth they are not. But now, astronomers can use the color key in the search for life outside our world—making an exoplanet’s clouds, in addition to its surface and air, a promising realm for finding signs of life.

“There is a vibrant community of microorganisms in our atmosphere that...

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X-ray techniques map and measure the invisible properties of altermagnets

Two new tools to map and measure the invisible properties of altermagnets
Calculated RPED patterns of MnTe for circular po-larized light with helicity q || L~ [1100] at the L3-resonance ( hbar omega = 639.7eV a-d) or the L2-resonance ( hbar omega = 651.8eV e-h). Credit: Physical Review Letters (2025). DOI: 10.1103/pl1p-v5rs

The new big thing in magnetics is altermagnetism, a form of magnetism that promises to power the next-generation of electronics. Unlike ferromagnets, like a fridge magnet, where all internal atomic spins align to create a strong magnetic field, altermagnets have no net magnetic pull (strongly magnetic on the inside, but appears non-magnetic on the outside). This is similar to antiferromagnets where internal spins cancel each other out...

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