The Key to Increased Lifespan? Rubicon Alters Autophagy in Animals during Aging


Age-dependent increase in expression of Rubicon, a negative regulator of autophagy, is a cause of age-dependent autophagic impairment and contributes to acceleration of aging in animals. Credit:
Osaka University

Autophagy is an important biological recycling mechanism that is used to maintain homeostasis (balance or equilibrium) within all types of animal tissue. Many studies have attempted to understand the relationship between the reduction of autophagy and progression of aging in animals; however, none have provided a clear explanation, until now.

In 2009, a research team led by Tamotsu Yoshimori at Osaka University identified Rubicon as a protein factor that suppresses autophagy by controlling a specific step in this pathway...

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Confirming a Source of the Process behind Auroras and the Formation of Stars

Figure 4
Ionization fraction and system size dependence of (a) the global reconnection rate, (b) the local inflow velocity, and (c) the ion diffusion region thickness for series B–D. 

Fast magnetic reconnection, the rapid convergence, separation and explosive snapping together of magnetic field lines, gives rise to northern lights, solar flares and geomagnetic storms that can disrupt cell phone service and electric power grids. The phenomenon takes place in plasma, the state of matter composed of free electrons and atomic nuclei, or ions, that makes up 99 percent of the visible universe. But whether fast reconnection can occur in partially ionized plasma – plasma that includes atoms as well as free electrons and ions – is not well understood.

Researchers at the U.S...

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Gearing up for 5G: A Miniature, Low-Cost Transceiver for Fast, Reliable Communications

Image of the new transceiver designed for 5G

Image of the new transceiver designed for 5G
The transceiver consists of a total of four horizontal (H1–4) and four vertical (V1–4) array orientations.

Researchers at Tokyo Institute of Technology (Tokyo Tech) have designed a 28 GHz transceiver that integrates beamforming with dual-polarized multiple-input and multiple-output, MIMO technology. Measuring just 3 mm by 4 mm, this tiny transceiver could help improve performances of fifth-generation cellular network (5G) and Internet of Things (IoT) devices.

A team of researchers led by Kenichi Okada at Tokyo Tech’s Department of Electrical and Electronic Engineering has devised a strategy with a clear eye on supporting high-speed mobile data access using the millimeter-wave spectrum for 5G, the highly-anticipated wireless network o...

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Why Getting Enough Sleep Reduces Cardiovascular Disease Risk

Images of plaque from the artery of a mouse model of atherosclerosis that experienced a normal sleeping pattern (left) and an image of arterial plaque from a mouse model that underwent sleep fragmentation (right). The amount of arterial plaque in the sleep-fragmented mouse is significantly larger.
Credit: Filip Swirski, Ph.D., Harvard Medical School

Sleep-modulating hormone hypocretin found to also control production of inflammatory cells. Getting enough sleep is key to good health, and studies have shown that insufficient sleep increases the risk of serious problems, including cardiovascular disease. Now Massachusetts General Hospital (MGH) investigators have discovered one way that sleep protects against the buildup of arterial plaques called atherosclerosis...

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