AHR limits microglial pro-inflammatory transcriptional responses during EAE.

A study published this week in Nature sheds new light on the connection between the gut and the brain, untangling the complex interplay that allows the byproducts of microorganisms living in the gut to influence the progression of neurodegenerative diseases. Investigators from Brigham and Women’s Hospital (BWH) have been using both animal models and human cells from patients to tease out the key players involved in the gut-brain connection as well as in the crosstalk between immune cells and brain cells. Their new publication defines a pathway that may help guide therapies for multiple sclerosis and other neurologic diseases.

The new research focuses on the influence of gut microbes on two types of cells that play...

These six images represent the variety of star-forming regions in nearby galaxies. The galaxies are part of the Hubble Space Telescope’s Legacy ExtraGalactic UV Survey (LEGUS), the sharpest, most comprehensive ultraviolet-light survey of star-forming galaxies in the nearby universe. The six images consist of two dwarf galaxies (UGC 5340 and UGCA 281) and four large spiral galaxies (NGC 3368, NGC 3627, NGC 6744, and NGC 4258). The images are a blend of ultraviolet light and visible light from Hubble’s Wide Field Camera 3 and Advanced Camera for Surveys. Credit: NASA/ESA/LEGUS team

Capitalizing on the unparalleled sharpness and spectral range of NASA’s Hubble Space Telescope, an international team of astronomers is releasing the most comprehensive, high-resolution UV-light survey of nearby s...

Gas in the Orion A cloud star-forming region. Each of the three colors (red, green and blue) represents a different velocity range. Credit: NSF/S. Kong, J. Feddersen, H. Arce & CARMA-NRO Orion Survey team

A Yale-led research group has created the most detailed maps yet of a vast seedbed of stars similar to Earth’s Sun. The maps provide unprecedented detail of the structure of the Orion A molecular cloud, the closest star-forming region of high-mass stars. Orion A hosts a variety of star-forming environments, including dense star clusters similar to the one where Earth’s Sun is believed to have formed...

This is a bird’s eye view of a microwell plate containing kidney organoids, generated by liquid handling robots from human stem cells. Yellow boxed region is shown at higher magnification. Red, green, and yellow colors mark distinct segments of the kidney. Credit: Freedman Lab/UW Medicine

Robotic approach could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system...