This graphical abstract depicts the effects of a 2-year calorie restriction (CR) trial in healthy, non-obese humans, which found evidence that prolonged CR enhances resting energy efficiency, resulting in decreased oxidative damage to tissues and organs. Credit: Redman et al./Cell Metabolism

One of the first studies to explore the effects of calorie restriction on humans showed that cutting caloric intake by 15% for 2 years slowed aging and metabolism and protected against age-related disease. The study, which will appear March 22 in the journal Cell Metabolism, found that calorie restriction decreased systemic oxidative stress, which has been tied to age-related neurological conditions such as Alzheimer’s and Parkinson’s diseases, as well as cancer, diabetes, and others.

“Restricting calo...

Space Observatory Captures the Details of an Unusual Stellar Detonation

The universe is full of mysterious exploding phenomena that go boom in the dark. One particular type of ephemeral event, called a Fast-Evolving Luminous Transient (FELT), has bewildered astronomers for a decade because of its very brief duration. Now, NASA’s Kepler Space Telescope—designed to go hunting for planets across our galaxy—has also been used to catch FELTs in the act and determine their nature. They appear to be a new kind of supernova that gets a brief turbo boost in brightness from its surroundings.

Kepler’s ability to precisely sample sudden changes in starlight has allowed astronomers to quickly arrive at this model for explaining FELTs, and rule out alternative explanations...

An MIT-led research team reversed age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

Activating proteins linked to longevity may help to increase endurance and combat frailty in the elderly. As we get older, our endurance declines, in part because our blood vessels lose some of their capacity to deliver oxygen and nutrients to muscle tissue. An MIT-led research team has now found that it can reverse this age-related endurance loss in mice by treating them with a compound that promotes new blood vessel growth. The compound, which re-activates longevity-linked proteins called sirtuins, promotes the growth of blood vessels and muscle, boosting the endurance of elderly mice by up to 80%.

If the findings translate to humans, this restorati...

Researchers have developed multifunctional origami structures, which they then fabricated into 4D printed objects. The design principle mimics the structure of an earwig’s wing. When open, the earwig wing expands 10X larger than when closed – one of the highest folding ratios in the animal kingdom. The large wing area allows the insect to fly, while the compact way the wings retracts enables the creature to tunnel underground without damaging its wings. The wing design has another unique feature; however, in its open, locked state the wing remains stiff with no need for muscle power to provide stability. With just one “click,” the wing folds into itself completely, without muscular actuation.

Researchers at ETH Zurich and Purdue University have been studying the secret of the earwig’s ori...